ZFIN ID: ZDB-LAB-080627-1
Tiso Lab
PI/Director: Tiso, Natascia
Contact Person: Tiso, Natascia
Email: natascia.tiso@unipd.it
URL: http://www.bio.unipd.it/development/
Address: Developmental Genetics Lab Department of Biology University of Padova via U. Bassi 58/B Padova I-35121 Italy
Country: Italy
Phone: +39 049 827 6302
Fax: +39 049 827 6199
Line Designation: ia


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
Our research interests mainly concern signaling pathway analysis and disease modeling in zebrafish, with particular attention to the neural, pancreatic, thyroidal, cardiac and mitochondrial compartment.
These studies are carried out by mRNA and morpholino microinjection, microarray strategies, single or double whole mount in situ hybridisation in zebrafish embryos, xeno-transplantations, Crispr/Cas9 genome editing, analysis of mutants and production of pathway reporter transgenic lines.


LAB MEMBERS
Zatti, Carlo MD/Veterinarian Beffagna, Giorgia Post-Doc Busolin, Giorgia Post-Doc
Facchinello, Nicola Post-Doc Giuliodori, Alice Post-Doc Porazzi, Patrizia Post-Doc
Colletti, Elisa Graduate Student Ek, Olivier Graduate Student Milanetto, Martina Fish Facility Staff
Pivotti, Luigi Fish Facility Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Herkenne, S., Ek, O., Zamberlan, M., Pellattiero, A., Chergova, M., Chivite, I., Novotná, E., Rigoni, G., Fonseca, T.B., Samardzic, D., Agnellini, A., Bean, C., Di Benedetto, G., Tiso, N., Argenton, F., Viola, A., Soriano, M.E., Giacomello, M., Ziviani, E., Sales, G., Claret, M., Graupera, M., Scorrano, L. (2020) Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metabolism. 31(5):987-1003.e8
Adusumilli, L., Facchinello, N., Teh, C., Busolin, G., Le, M.T., Yang, H., Beffagna, G., Campanaro, S., Tam, W.L., Argenton, F., Lim, B., Korzh, V., Tiso, N. (2020) miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 9(3):
Valenti, M.T., Marchetto, G., Perduca, M., Tiso, N., Mottes, M., Dalle Carbonare, L. (2020) BEL β-Trefoil Reduces the Migration Ability of RUNX2 Expressing Melanoma Cells in Xenotransplanted Zebrafish. Molecules. 25(6):
Morbiato, E., Frigato, E., Dinarello, A., Maradonna, F., Facchinello, N., Argenton, F., Carnevali, O., Dalla Valle, L., Bertolucci, C. (2019) Feeding Entrainment of the Zebrafish Circadian Clock Is Regulated by the Glucocorticoid Receptor. Cells. 8(11):
Gavryusev, V., Sancataldo, G., Ricci, P., Montalbano, A., Fornetto, C., Turrini, L., Laurino, A., Pesce, L., de Vito, G., Tiso, N., Vanzi, F., Silvestri, L., Pavone, F.S. (2019) Dual-beam confocal light-sheet microscopy via flexible acousto-optic deflector. Journal of Biomedical Optics. 24:1-6
Beffagna, G. (2019) Zebrafish as a Smart Model to Understand Regeneration After Heart Injury: How Fish Could Help Humans. Frontiers in cardiovascular medicine. 6:107
Santoro, M.M., Beltrame, M., Panáková, D., Siekmann, A.F., Tiso, N., Venero Galanternik, M., Jung, H.M., Weinstein, B.M. (2019) Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in cell and developmental biology. 7:89
Vetrivel, S., Tiso, N., Kügler, A., Irmler, M., Horsch, M., Beckers, J., Hladik, D., Giesert, F., Gailus-Durner, V., Fuchs, H., Sabrautzki, S., German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany, Adler, T., Treise, I., Busch, D.H., Aguilar-Pimentel, A., Ollert, M., Götz, A., Amarie, O.V., Stoeger, T., Schulz, H., Becker, L., Klopstock, T., Schrewe, A., Spielmann, N., Bekeredjian, R., Garrett, L., Hölter, S.M., Zimprich, A., Wurst, W., Mayer-Kuckuk, P., Hans, W., Rozman, J., Klingenspor, M., Neff, F., da Silva-Buttkus, P., Calzada-Wack, J., Rácz, I., Zimmer, A., Rathkolb, B., Wolf, E., Prehn, C., Adamski, J., Östereicher, M., Miller, G., Steinkamp, R., Lengger, C., Maier, H., Stoeger, C., Leuchtenberger, S., Gailus-Durner, V., Fuchs, H., Hrabě de Angelis, M., Hrabě de Angelis, M., Graw, J. (2019) Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Experimental Eye Research. 188:107632
Martorano, L., Peron, M., Laquatra, C., Lidron, E., Facchinello, N., Meneghetti, G., Tiso, N., Rasola, A., Ghezzi, D., Argenton, F. (2019) The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria. Disease models & mechanisms. 12(3):
Meneghetti, G., Skobo, T., Chrisam, M., Facchinello, N., Fontana, C.M., Bellesso, S., Sabatelli, P., Raggi, F., Cecconi, F., Bonaldo, P., Dalla Valle, L. (2019) The epg5 knockout zebrafish line: a model to study Vici syndrome. Autophagy. 15(8):1438-1454
Müllenbroich, M.C., Turrini, L., Silvestri, L., Alterini, T., Gheisari, A., Tiso, N., Vanzi, F., Sacconi, L., Pavone, F.S. (2019) Corrigendum: Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy. Frontiers in Cellular Neuroscience. 13:25
Sancataldo, G., Gavryusev, V., de Vito, G., Turrini, L., Locatelli, M., Fornetto, C., Tiso, N., Vanzi, F., Silvestri, L., Pavone, F.S. (2019) Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts. Frontiers in Neuroanatomy. 13:7
Deiana, M., Dalle Carbonare, L., Serena, M., Cheri, S., Parolini, F., Gandini, A., Marchetto, G., Innamorati, G., Manfredi, M., Marengo, E., Brandi, J., Cecconi, D., Mori, A., Mina, M.M., Antoniazzi, F., Mottes, M., Tiso, N., Malerba, G., Zipeto, D., Valenti, M.T. (2018) New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration. Cells. 7(11)
Müllenbroich, M.C., Turrini, L., Silvestri, L., Alterini, T., Gheisari, A., Vanzi, F., Sacconi, L., Pavone, F.S. (2018) Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy. Frontiers in Cellular Neuroscience. 12:315
Diquigiovanni, C., Bergamini, C., Evangelisti, C., Isidori, F., Vettori, A., Tiso, N., Argenton, F., Costanzini, A., Iommarini, L., Anbunathan, H., Pagotto, U., Repaci, A., Babbi, G., Casadio, R., Lenaz, G., Rhoden, K.J., Porcelli, A.M., Fato, R., Bowcock, A., Seri, M., Romeo, G., Bonora, E. (2018) Mutant MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer. International Journal of Cancer. 143(7):1706-1719
Facchinello, N., Skobo, T., Meneghetti, G., Colletti, E., Dinarello, A., Tiso, N., Costa, R., Gioacchini, G., Carnevali, O., Argenton, F., Colombo, L., Valle, L.D. (2018) Author Correction: nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor. Scientific Reports. 8:4445
Giuliodori, A., Beffagna, G., Marchetto, G., Fornetto, C., Vanzi, F., Toppo, S., Facchinello, N., Santimaria, M., Vettori, A., Rizzo, S., Della Barbera, M., Pilichou, K., Argenton, F., Thiene, G., Tiso, N., Basso, C. (2018) Loss of cardiac Wnt/β-catenin signalling in Desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention. Cardiovascular research. 114(8):1082-1097
Vettori, A., Greenald, D., Wilson, G.K., Peron, M., Facchinello, N., Markham, E., Sinnakaruppan, M., Matthews, L.C., McKeating, J.A., Argenton, F., van Eeden, F.J.M. (2017) Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization. Proceedings of the National Academy of Sciences of the United States of America. 114(37):9948-9953
Facchinello, N., Tarifeño-Saldivia, E., Grisan, E., Schiavone, M., Peron, M., Mongera, A., Ek, O., Schmitner, N., Meyer, D., Peers, B., Tiso, N., Argenton, F. (2017) Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration. Scientific Reports. 7:9605
Ghosal, S., Banerjee, S., Tiso, N., Grisan, E., Chowdhury, A.S. (2017) A novel non-rigid registration algorithm for zebrafish larval images. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2017:321-324
Facchinello, N., Skobo, T., Meneghetti, G., Colletti, E., Dinarello, A., Tiso, N., Costa, R., Gioacchini, G., Carnevali, O., Argenton, F., Colombo, L., Dalla Valle, L. (2017) nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor. Scientific Reports. 7:4371
Turrini, L., Fornetto, C., Marchetto, G., Müllenbroich, M.C., Tiso, N., Vettori, A., Resta, F., Masi, A., Mannaioni, G., Pavone, F.S., Vanzi, F. (2017) Optical mapping of neuronal activity during seizures in zebrafish. Scientific Reports. 7:3025
Delfino-Machín, M., Madelaine, R., Busolin, G., Nikaido, M., Colanesi, S., Camargo-Sosa, K., Law, E.W., Toppo, S., Blader, P., Tiso, N., Kelsh, R.N. (2017) Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors. PLoS One. 12:e0172947
Khatri, D., Zizioli, D., Tiso, N., Facchinello, N., Vezzoli, S., Gianoncelli, A., Memo, M., Monti, E., Borsani, G., Finazzi, D. (2016) Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish. Scientific Reports. 6:37660
Saltari, A., Truzzi, F., Quadri, M., Lotti, R., Palazzo, E., Grisendi, G., Tiso, N., Marconi, A., Pincelli, C. (2016) CD271 downregulation promotes melanoma progression and invasion in 3-dimensional models and in zebrafish. The Journal of investigative dermatology. 136(10):2049-58
de Filippis, T., Marelli, F., Nebbia, G., Porazzi, P., Corbetta, S., Fugazzola, L., Gastaldi, R., Vigone, M.C., Biffanti, R., Frizziero, D., Mandarà, L., Prontera, P., Salerno, M., Maghnie, M., Tiso, N., Radetti, G., Weber, G., Persani, L. (2016) JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects. The Journal of clinical endocrinology and metabolism. 101(3):861-70
Pozzobon, T., Facchinello, N., Bossi, F., Capitani, N., Benagiano, M., Di Benedetto, G., Zennaro, C., West, N., Codolo, G., Bernardini, M., Baldari, C.T., D'Elios, M.M., Pellegrini, L., Argenton, F., de Bernard, M. (2016) Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway. Scientific Reports. 6:18785
Facchinello, N., Schiavone, M., Vettori, A., Argenton, F., Tiso, N. (2016) Monitoring Wnt Signaling in Zebrafish Using Fluorescent Biosensors. Methods in molecular biology (Clifton, N.J.). 1481:81-94
Zizioli, D., Tiso, N., Guglielmi, A., Saraceno, C., Busolin, G., Giuliani, R., Khatri, D., Monti, E., Borsani, G., Argenton, F., Finazzi, D. (2016) Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease. Neurobiology of disease. 85:35-48
Astone, M., Pizzi, M., Peron, M., Domenichini, A., Guzzardo, V., Töchterle, S., Tiso, N., Rugge, M., Meyer, D., Argenton, F., Vettori, A. (2015) A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish. PLoS One. 10:e0145178
Hen, G., Nicenboim, J., Mayseless, O., Asaf, L., Shin, M., Busolin, G., Hofi, R., Almog, G., Tiso, N., Lawson, N.D., Yaniv, K. (2015) Venous-derived angioblasts generate organ-specific vessels during embryonic development. Development (Cambridge, England). 142(24):4266-78
Casari, A., Schiavone, M., Facchinello, N., Vettori, A., Meyer, D., Tiso, N., Moro, E., Argenton, F. (2014) A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development. Developmental Biology. 396(1):81-93
Benato, F., Colletti, E., Skobo, T., Moro, E., Colombo, L., Argenton, F., Dalla Valle, L. (2014) A living biosensor model to dynamically trace glucocorticoid transcriptional activity during development and adult life in zebrafish. Molecular and Cellular Endocrinology. 392(1-2):60-72
Schiavone, M., Rampazzo, E., Casari, A., Battilana, G., Persano, L., Moro, E., Liu, S., Leach, S.D., Tiso, N., Argenton, F. (2014) Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer. Disease models & mechanisms. 7(7):883-94
Moro, E., Vettori, A., Porazzi, P., Schiavone, M., Rampazzo, E., Casari, A., Ek, O., Facchinello, N., Astone, M., Zancan, I., Milanetto, M., Tiso, N., and Argenton, F. (2013) Generation and application of signaling pathway reporter lines in zebrafish. Molecular genetics and genomics : MGG. 288(5-6):231-242
Cavodeassi, F., Bene, F.D., Fürthauer, M., Grabher, C., Herzog, W., Lehtonen, S., Linker, C., Mercader, N., Mikut, R., Norton, W., Strähle, U., Tiso, N., and Foulkes, N.S. (2013) Report of the Second European Zebrafish Principal Investigator Meeting in Karlsruhe, Germany, March 21-24, 2012. Zebrafish. 10(1):119-23
Rampazzo, E., Persano, L., Pistollato, F., Moro, E., Frasson, C., Porazzi, P., Della Puppa, A., Bresolin, S., Battilana, G., Indraccolo, S., Te Kronnie, G., Argenton, F., Tiso, N., and Basso, G. (2013) Wnt activation promotes neuronal differentiation of Glioblastoma. Cell Death & Disease. 4:e500
Porazzi, P., Marelli, F., Benato, F., de Filippis, T., Calebiro, D., Argenton, F., Tiso, N., and Persani, L. (2012) Disruptions of Global and Jagged1-Mediated Notch Signaling Affect Thyroid Morphogenesis in the Zebrafish. Endocrinology. 153(11):5645-5658
Moro, E., Özhan, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R.M., Bournele, D., Domenichini, A., Valdivia, L.E., Lum, L., Chen, C., Amatruda, J.F., Tiso, N., Weidinger, G., and Argenton, F. (2012) In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Developmental Biology. 366(2):327-340
Arkhipova, V., Wendik, B., Devos, N., Ek, O., Peers, B., and Meyer, D. (2012) Characterization and regulation of the hb9/mnx1 beta-cell progenitor specific enhancer in zebrafish. Developmental Biology. 365(1):290-302
Robinson, B.W., Germano, G., Song, Y., Abrams, J., Scott, M., Guariento, I., Tiso, N., Argenton, F., Basso, G., Rhodes, J., Kanki, J.P., Look, A.T., Balice-Gordon, R.J., and Felix, C.A. (2011) mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues. British journal of haematology. 152(3):307-321
Vettori, A., Bergamin, G., Moro, E., Vazza, G., Polo, G., Tiso, N., Argenton, F., and Mostacciuolo, M.L. (2011) Developmental defects and neuromuscular alterations due to mitofusin 2 gene (MFN2) silencing in zebrafish: A new model for Charcot-Marie-Tooth type 2A neuropathy. Neuromuscular disorders : NMD. 21(1):58-67
Vaccari, E., Deflorian, G., Bernardi, E., Pauls, S., Tiso, N., Bortolussi, M., and Argenton, F. (2010) prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish. Developmental Biology. 343(1-2):94-103
Verbruggen, V., Ek, O., Georlette, D., Delporte, F., Von Berg, V., Detry, N., Biemar, F., Coutinho, P., Martial, J.A., Voz, M.L., Manfroid, I., and Peers, B. (2010) The Pax6b homeodomain is dispensable for pancreatic endocrine cell differentiation in zebrafish. The Journal of biological chemistry. 285(18):13863-13873
Moro, E., Tomanin, R., Friso, A., Modena, N., Tiso, N., Scarpa, M., and Argenton, F. (2010) A novel functional role of iduronate-2-sulfatase in zebrafish early development. Matrix biology : journal of the International Society for Matrix Biology. 29(1):43-50
Porazzi, P., Calebiro, D., Benato, F., Tiso, N., and Persani, L. (2009) Thyroid gland development and function in the zebrafish model. Molecular and Cellular Endocrinology. 312(1-2):14-23
Tiso, N., Moro, E., and Argenton, F. (2009) Zebrafish Pancreas Development. Molecular and Cellular Endocrinology. 312(1-2):24-30
Tiso, N., Filippi, A., Benato, F., Negrisolo, E., Modena, N., Vaccari, E., Driever, W., and Argenton, F. (2009) Differential expression and regulation of olig genes in zebrafish. The Journal of comparative neurology. 515(3):378-396
Milanetto, M., Tiso, N., Braghetta, P., Volpin, D., Argenton, F., and Bonaldo, P. (2008) Emilin genes are duplicated and dynamically expressed during zebrafish embryonic development. Developmental dynamics : an official publication of the American Association of Anatomists. 237(1):222-232
Manzoni, M., Colombi, P., Papini, N., Rubaga, L., Tiso, N., Preti, A., Venerando, B., Tettamanti, G., Bresciani, R., Argenton, F., Borsani, G., and Monti, E. (2007) Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). The Biochemical journal. 408(3):395-406
Pauls, S., Zecchin, E., Tiso, N., Bortolussi, M., and Argenton, F. (2007) Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts. Developmental Biology. 304(2):875-890
Zecchin, E., Filippi, A., Biemar, F., Tiso, N., Pauls, S., Ellertsdottir, E., Gnugge, L., Bortolussi, M., Driever, W., and Argenton, F. (2007) Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish. Developmental Biology. 301(1):192-204
Romano, A., Kottra, G., Barca, A., Tiso, N., Maffia, M., Argenton, F., Daniel, H., Storelli, C., and Verri, T. (2006) The high-affinity peptide transporter PEPT2 (SLC15A2) of the zebrafish Danio rerio: functional properties, genomic organization and expression analysis. Physiological Genomics. 24(3):207-217
Zecchin, E., Conigliaro, A., Tiso, N., Argenton, F., and Bortolussi, M. (2005) Expression analysis of jagged genes in zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 233(2):638-645
Filippi, A., Tiso, N., Deflorian, G., Zecchin, E., Bortolussi, M., and Argenton, F. (2005) The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord. Proceedings of the National Academy of Sciences of the United States of America. 102(12):4377-4382
Zecchin, E., Mavropoulos, A., Devos, N., Filippi, A., Tiso, N., Meyer, D., Peers, B., Bortolussi, M., Argenton, F. (2004) Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Developmental Biology. 268(1):174-184
Deflorian, G., Tiso, N., Ferretti, E., Meyer, D., Blasi, F., Bortolussi, M., and Argenton, F. (2004) Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Development (Cambridge, England). 131(3):613-627
Verri, T., Kottra, G., Romano, A., Tiso, N., Peric, M., Maffia, M., Boll, M., Argenton, F., Daniel, H., and Storelli, C. (2003) Molecular and functional characterisation of the zebrafish (Danio rerio) PEPT1-type peptide transporter. FEBS letters. 549(1-3):115-122
Tiso, N., Filippi, A., Pauls, S., Bortolussi, M., and Argenton, F. (2002) BMP signalling regulates anteroposterior endoderm patterning in zebrafish. Mechanisms of Development. 118(1-2):29-37