Cell Surface Signalling Laboratory
The Morgan Building
Wellcome Trust Sanger Institute
Cambridge CB10 1HH
+44 (0)1223 496852
+44 (0)1223 496802
GENOMIC FEATURES ORIGINATING FROM THIS LABNo data available
STATEMENT OF RESEARCH INTERESTS
The main interest of the laboratory is the discovery of novel extracellular receptor:ligand interactions that initiate communication between the cells and tissues within vertebrate organisms. Genes encoding proteins that are secreted or tethered to the cell surface are estimated to account for approximately a fifth of all vertebrate genes and yet they remain largely understudied, primarily due to their complex biochemical nature.
We have developed a research programme to allow a large-scale approach to studying these proteins and particularly their extracellular interactions. We have chosen to use the zebrafish as our model organism so that the functional consequences of any interactions can be more readily determined.