ZFIN ID: ZDB-LAB-050202-1
Lab D38
PI/Director: Chico, Tim J.
Contact Person: Chico, Tim J.
Email: t.j.chico@sheffield.ac.uk
URL:
Address: Bateson Centre Firth Court University of Sheffield Sheffield, S10 2TF United Kingdom
Country: United Kingdom
Phone: 00 44 114 222 2395
Fax: 00 44 114 261 9587
Line Designation: sh


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 6 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS
Gray, Caroline Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Chhabria, K., Vouros, A., Gray, C., MacDonald, R.B., Jiang, Z., Wilkinson, R.N., Plant, K., Vasilaki, E., Howarth, C., Chico, T.J.A. (2019) Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. Disease models & mechanisms. 12(9):
Kugler, E.C., van Lessen, M., Daetwyler, S., Chhabria, K., Savage, A.M., Silva, V., Plant, K., MacDonald, R.B., Huisken, J., Wilkinson, R.N., Schulte-Merker, S., Armitage, P., Chico, T.J. (2019) Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish. EMBO reports. 20:e47047
Elworthy, S., Savage, A.M., Wilkinson, R.N., Malicki, J.J., Chico, T.J.A. (2019) The role of endothelial cilia in post-embryonic vascular development. Developmental dynamics : an official publication of the American Association of Anatomists. 248(6):410-425
Savage, A.M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R.B., Kim, H.R., Wilson, H.L., van Eeden, F.J.M., Armesilla, A.L., Chico, T.J.A., Wilkinson, R.N. (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature communications. 10:732
Neal, A., Nornes, S., Payne, S., Wallace, M.D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R.N., Chouliaras, K.M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Bond, G., Chico, T., Bou-Gharios, G., De Val, S. (2019) Venous identity requires BMP signalling through ALK3. Nature communications. 10:453
Chhabria, K., Plant, K., Bandmann, O., Wilkinson, R.N., Martin, C., Kugler, E., Armitage, P.A., Santoscoy, P.L., Cunliffe, V.T., Huisken, J., McGown, A., Ramesh, T., Chico, T.J., Howarth, C. (2018) The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 40(2):298-313
Brown, H.K., Schiavone, K., Tazzyman, S., Heymann, D., Chico, T.J. (2017) Zebrafish xenograft models of cancer and metastasis for drug discovery. Expert opinion on drug discovery. 12(4):379-389
Serbanovic-Canic, J., de Luca, A., Warboys, C., Ferreira, P.F., Luong, L.A., Hsiao, S., Gauci, I., Mahmoud, M., Feng, S., Souilhol, C., Bowden, N., Ashton, J.P., Walczak, H., Firmin, D., Krams, R., Mason, J.C., Haskard, D.O., Sherwin, S., Ridger, V., Chico, T.J., Evans, P.C. (2017) Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arteriosclerosis, Thrombosis, and Vascular Biology. 37(1):130-143
Dee, C.T., Nagaraju, R.T., Athanasiadis, E.I., Gray, C., Fernandez Del Ama, L., Johnston, S.A., Secombes, C.J., Cvejic, A., Hurlstone, A.F. (2016) CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. Journal of immunology (Baltimore, Md. : 1950). 197(9):3520-3530
Mahmoud, M., Kim, H.R., Xing, R., Hsiao, S., Mammmoto, A., Chen, J., Serbanovic-Canic, J., Feng, S., Bowden, N.P., Maguire, R., Ariaans, M., Francis, S., Weinberg, P.D., Van der Heiden, K., Jones, E.A., Chico, T.J., Ridger, V.C., Evans, P.C. (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation research. 119(3):450-62
Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611
Gray, C. (2015) New insights into blood vessel remodelling during development and disease using the zebrafish.. Ph.D. Thesis.
Ogryzko, N.V., Hoggett, E.E., Solaymani-Kohal, S., Tazzyman, S., Chico, T.J., Renshaw, S.A., and Wilson, H.L. (2014) Zebrafish tissue injury causes up-regulation of interleukin-1 and caspase dependent amplification of the inflammatory response. Disease models & mechanisms. 7(2):259-64
Gorsi, B., Liu, F., Ma, X., Chico, T.J., Shrinivasan, A., Kramer, K.L., Bridges, E., Monteiro, R., Harris, A.L., Patient, R., and Stringer, S.E. (2014) The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity. Angiogenesis. 17(1):77-91
Watson, O., Novodvorsky, P., Gray, C., Rothman, A.M., Lawrie, A., Gerhardt, H., Crossman, D.C., Haase, A., McMahon, K., Gering, M., van Eeden, F.J., and Chico, T.J. (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling. Cardiovascular research. 100(2):252-61
Gray, C., Bratt, D., Lees, J., Dacosta, M., Plant, K., Solaymani-Kohal, S., Tazzyman, S., Serbanovic-Canic, J., Crossman, D.C., Keavney, B.D., Haase, A., McMahon, K., Gering, M., Roehl, H., Evans, P.C., and Chico, T.J. (2013) Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development. Arterioscler. Thromb. Vasc. Biol.. 33(6):1257-63
Novodvorsky, P., da Costa, M.M.J., and Chico, T.J.A. (2013) Zebrafish-based small molecule screens for novel cardiovascular drugs. Drug Discovery Today: Technologies. 10(1):e109-e114
Quaife, N.M., Watson, O., and Chico, T.J. (2012) Zebrafish: an emerging model of vascular development and remodelling. Current opinion in pharmacology. 12(5):608-614
Bugeon, L., Taylor, H.B., Progatzky, F., Lin, M.I., Ellis, C.D., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S.A., Chico, T.J., Zon, L., Lamb, J., and Dallman, M.J. (2011) The NOTCH pathway contributes to cell fate decisions in myelopoiesis. Haematologica. 96(12):1753-60
Bratt, D.G., Lees, J., Crossman, D.C., Gering, M., and Chico, T.J. (2011) 18 Parathyroid hormone receptor 1 knockdown induces localised aortic occlusion by down regulating notch signalling in zebrafish. Heart (British Cardiac Society). 97(20):e7
Holden, B.J., van Eeden, F.J., Ong, A.C., and Chico, T.J. (2011) 32 PKD2 mutant zebrafish display excessive developmental angiogenesis. Heart (British Cardiac Society). 97(20):e7
Lara, R., Mauri, F.A., Taylor, H., Derua, R., Shia, A., Gray, C., Nicols, A., Shiner, R.J., Schofield, E., Bates, P.A., Waelkens, E., Dallman, M., Lamb, J., Zicha, D., Downward, J., Seckl, M.J., and Pardo, O.E. (2011) An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis. Oncogene. 30(32):3513-21
Holden, B.J., Bratt, D.G., and Chico, T.J. (2011) Molecular control of vascular development in the zebrafish. Birth defects research. Part C, Embryo today : reviews. 93(2):134-140
Gray, C., Loynes, C.A., Whyte, M.K., Crossman, D.C., Renshaw, S.A., and Chico, T.J. (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish. Thrombosis and haemostasis. 105(5):811-819
Chico, T.J., Milo, M., and Crossman, D.C. (2010) The genetics of cardiovascular disease: new insights from emerging approaches. The Journal of pathology. 220(2):186-197
Packham, I.M., Gray, C., Heath, P.R., Hellewell, P.G., Ingham, P.W., Crossman, D.C., Milo, M., and Chico, T.J. (2009) Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos. Physiological Genomics. 38(3):319-327
Rocke, J., Lees, J., Packham, I., and Chico, T. (2009) The zebrafish as a novel tool for cardiovascular drug discovery. Recent advances in cardiovascular drug discovery. 4(1):1-5
Chico, T.J., Ingham, P.W., and Crossman, D.C. (2008) Modeling cardiovascular disease in the zebrafish. Trends in cardiovascular medicine. 18(4):150-155
Gray, C., Packham, I.M., Wurmser, F., Eastley, N.C., Hellewell, P.G., Ingham, P.W., Crossman, D.C., and Chico, T.J. (2007) Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos. Arterioscler. Thromb. Vasc. Biol.. 27(10):2135-2141