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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-050131-3
Chico, Tim J.
Email: t.j.chico@sheffield.ac.uk
URL:
Affiliation: Lab D38
Address: Centre for Biomedical and Developmental Genetics Firth Court University of Sheffield Sheffield, S10 2TF United Kingdom
Country: United Kingdom
Phone: 00 44 114 222 2395
Fax: 00 44 114 261 9587
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
My research investigates the genetic contributors to arteriogenesis (collateral vessel formation after arterial occlusion) in the zebrafish.


PUBLICATIONS
Kugler, E.C., van Lessen, M., Daetwyler, S., Chhabria, K., Savage, A.M., Silva, V., Plant, K., MacDonald, R.B., Huisken, J., Wilkinson, R.N., Schulte-Merker, S., Armitage, P., Chico, T.J. (2019) Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish. EMBO reports. 20:e47047
Elworthy, S., Savage, A.M., Wilkinson, R.N., Malicki, J.J., Chico, T.J.A. (2019) The role of endothelial cilia in post-embryonic vascular development. Developmental dynamics : an official publication of the American Association of Anatomists. 248(6):410-425
Savage, A.M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R.B., Kim, H.R., Wilson, H.L., van Eeden, F.J.M., Armesilla, A.L., Chico, T.J.A., Wilkinson, R.N. (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature communications. 10:732
Neal, A., Nornes, S., Payne, S., Wallace, M.D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R.N., Chouliaras, K.M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Bond, G., Chico, T., Bou-Gharios, G., De Val, S. (2019) Venous identity requires BMP signalling through ALK3. Nature communications. 10:453
Brown, H.K., Schiavone, K., Tazzyman, S., Heymann, D., Chico, T.J. (2017) Zebrafish xenograft models of cancer and metastasis for drug discovery. Expert opinion on drug discovery. 12(4):379-389
Serbanovic-Canic, J., de Luca, A., Warboys, C., Ferreira, P.F., Luong, L.A., Hsiao, S., Gauci, I., Mahmoud, M., Feng, S., Souilhol, C., Bowden, N., Ashton, J.P., Walczak, H., Firmin, D., Krams, R., Mason, J.C., Haskard, D.O., Sherwin, S., Ridger, V., Chico, T.J., Evans, P.C. (2017) Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arteriosclerosis, Thrombosis, and Vascular Biology. 37(1):130-143
Mahmoud, M., Kim, H.R., Xing, R., Hsiao, S., Mammmoto, A., Chen, J., Serbanovic-Canic, J., Feng, S., Bowden, N.P., Maguire, R., Ariaans, M., Francis, S., Weinberg, P.D., Van der Heiden, K., Jones, E.A., Chico, T.J., Ridger, V.C., Evans, P.C. (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation research. 119(3):450-62
Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611
Ogryzko, N.V., Hoggett, E.E., Solaymani-Kohal, S., Tazzyman, S., Chico, T.J., Renshaw, S.A., and Wilson, H.L. (2014) Zebrafish tissue injury causes up-regulation of interleukin-1 and caspase dependent amplification of the inflammatory response. Disease models & mechanisms. 7(2):259-64
Gorsi, B., Liu, F., Ma, X., Chico, T.J., Shrinivasan, A., Kramer, K.L., Bridges, E., Monteiro, R., Harris, A.L., Patient, R., and Stringer, S.E. (2014) The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity. Angiogenesis. 17(1):77-91
Watson, O., Novodvorsky, P., Gray, C., Rothman, A.M., Lawrie, A., Gerhardt, H., Crossman, D.C., Haase, A., McMahon, K., Gering, M., van Eeden, F.J., and Chico, T.J. (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling. Cardiovascular research. 100(2):252-61
Gray, C., Bratt, D., Lees, J., Dacosta, M., Plant, K., Solaymani-Kohal, S., Tazzyman, S., Serbanovic-Canic, J., Crossman, D.C., Keavney, B.D., Haase, A., McMahon, K., Gering, M., Roehl, H., Evans, P.C., and Chico, T.J. (2013) Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development. Arterioscler. Thromb. Vasc. Biol.. 33(6):1257-63
Novodvorsky, P., da Costa, M.M.J., and Chico, T.J.A. (2013) Zebrafish-based small molecule screens for novel cardiovascular drugs. Drug Discovery Today: Technologies. 10(1):e109-e114
Quaife, N.M., Watson, O., and Chico, T.J. (2012) Zebrafish: an emerging model of vascular development and remodelling. Current opinion in pharmacology. 12(5):608-614
Bugeon, L., Taylor, H.B., Progatzky, F., Lin, M.I., Ellis, C.D., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S.A., Chico, T.J., Zon, L., Lamb, J., and Dallman, M.J. (2011) The NOTCH pathway contributes to cell fate decisions in myelopoiesis. Haematologica. 96(12):1753-60
Holden, B.J., van Eeden, F.J., Ong, A.C., and Chico, T.J. (2011) 32 PKD2 mutant zebrafish display excessive developmental angiogenesis. Heart (British Cardiac Society). 97(20):e7
Bratt, D.G., Lees, J., Crossman, D.C., Gering, M., and Chico, T.J. (2011) 18 Parathyroid hormone receptor 1 knockdown induces localised aortic occlusion by down regulating notch signalling in zebrafish. Heart (British Cardiac Society). 97(20):e7
Holden, B.J., Bratt, D.G., and Chico, T.J. (2011) Molecular control of vascular development in the zebrafish. Birth defects research. Part C, Embryo today : reviews. 93(2):134-140
Gray, C., Loynes, C.A., Whyte, M.K., Crossman, D.C., Renshaw, S.A., and Chico, T.J. (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish. Thrombosis and haemostasis. 105(5):811-819
Chico, T.J., Milo, M., and Crossman, D.C. (2010) The genetics of cardiovascular disease: new insights from emerging approaches. The Journal of pathology. 220(2):186-197
Packham, I.M., Gray, C., Heath, P.R., Hellewell, P.G., Ingham, P.W., Crossman, D.C., Milo, M., and Chico, T.J. (2009) Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos. Physiological Genomics. 38(3):319-327
Rocke, J., Lees, J., Packham, I., and Chico, T. (2009) The zebrafish as a novel tool for cardiovascular drug discovery. Recent advances in cardiovascular drug discovery. 4(1):1-5
Chico, T.J., Ingham, P.W., and Crossman, D.C. (2008) Modeling cardiovascular disease in the zebrafish. Trends in cardiovascular medicine. 18(4):150-155
Gray, C., Packham, I.M., Wurmser, F., Eastley, N.C., Hellewell, P.G., Ingham, P.W., Crossman, D.C., and Chico, T.J. (2007) Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos. Arterioscler. Thromb. Vasc. Biol.. 27(10):2135-2141

NON-ZEBRAFISH PUBLICATIONS