ZFIN Lab: Bakkers Lab

ZFIN ID: ZDB-LAB-031010-1

Bakkers Lab

PI/Director:	Bakkers, Jeroen
Contact Person:	Bakkers, Jeroen
Email:	j.bakkers@hubrecht.eu
URL:	http://www.hubrecht.eu/research-groups/bakkers-group/
Address:	Hubrecht Laboratory Netherlands Institute for Developmental Biology Uppsalalaan 8 3584 CT, Utrecht THE NETHERLANDS
Country:	Netherlands
Phone:	31-30-212-1892
Fax:	31-30-212-1801
Line Designation:	hu

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 28 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Noël, Emily Post-Doc

Postel, Ruben Graduate Student

Chocron, Sonja Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Ratnayake, D., Nguyen, P.D., Rossello, F.J., Wimmer, V.C., Tan, J.L., Galvis, L.A., Julier, Z., Wood, A.J., Boudier, T., Isiaku, A.I., Berger, S., Oorschot, V., Sonntag, C., Rogers, K.L., Marcelle, C., Lieschke, G.J., Martino, M.M., Bakkers, J., Currie, P.D. (2021) Macrophages provide a transient muscle stem cell niche via NAMPT secretion. Nature. 591(7849):281-287

Bertozzi, A., Wu, C.C., Nguyen, P.D., Vasudevarao, M.D., Mulaw, M.A., Koopman, C.D., de Boer, T.P., Bakkers, J., Weidinger, G. (2020) Is zebrafish heart regeneration "complete"? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts. Developmental Biology. 471:106-118

Tessadori, F., de Bakker, D.E.M., Barske, L., Nelson, N., Algra, H.A., Willekers, S., Nichols, J.T., Crump, J.G., Bakkers, J. (2020) Zebrafish prrx1a mutants have normal hearts. Nature. 585:E14-E16

Andrés-Delgado, L., Galardi-Castilla, M., Münch, J., Peralta, M., Ernst, A., González-Rosa, J.M., Tessadori, F., Santamaría, L., Bakkers, J., Vermot, J., de la Pompa, J.L., Mercader, N. (2020) Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium. Developmental dynamics : an official publication of the American Association of Anatomists. 249(12):1455-1469

Honkoop, H., de Bakker, D.E., Aharonov, A., Kruse, F., Shakked, A., Nguyen, P.D., de Heus, C., Garric, L., Muraro, M.J., Shoffner, A., Tessadori, F., Peterson, J.C., Noort, W., Bertozzi, A., Weidinger, G., Posthuma, G., Grun, D., van der Laarse, W.J., Klumperman, J., Jaspers, R.T., Poss, K.D., van Oudenaarden, A., Tzahor, E., Bakkers, J. (2019) Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLIFE. 8:

Tessadori, F., Rehman, A.U., Giltay, J.C., Xia, F., Streff, H., Duran, K., Bakkers, J., Lalani, S.R., van Haaften, G. (2019) A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder. European journal of human genetics : EJHG. 28(5):674-678

Ciapaite, J., Albersen, M., Savelberg, S.M.C., Bosma, M., Tessadori, F., Gerrits, J., Lansu, N., Zwakenberg, S., Bakkers, J.P.W., Zwartkruis, F.J.T., van Haaften, G., Jans, J.J., Verhoeven-Duif, N.M. (2019) Pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations. Biochimica et biophysica acta. Molecular basis of disease. 1866(3):165607

Smeland, M.F., McClenaghan, C., Roessler, H.I., Savelberg, S., Hansen, G.Å.M., Hjellnes, H., Arntzen, K.A., Müller, K.I., Dybesland, A.R., Harter, T., Sala-Rabanal, M., Emfinger, C.H., Huang, Y., Singareddy, S.S., Gunn, J., Wozniak, D.F., Kovacs, A., Massink, M., Tessadori, F., Kamel, S.M., Bakkers, J., Remedi, M.S., Van Ghelue, M., Nichols, C.G., van Haaften, G. (2019) ABCC9-related Intellectual disability Myopathy Syndrome is a K_ATP channelopathy with loss-of-function mutations in ABCC9. Nature communications. 10:4457

van den Boogaard, M., van Weerd, J.H., Bawazeer, A.C., Hooijkaas, I.B., van de Werken, H.J.G., Tessadori, F., de Laat, W., Barnett, P., Bakkers, J., Christoffels, V.M. (2019) Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation. Cell Reports. 28:2704-2714.e5

Veerman, C.C., Mengarelli, I., Koopman, C.D., Wilders, R., van Amersfoorth, S.C., Bakker, D., Wolswinkel, R., Hababa, M., de Boer, T.P., Guan, K., Milnes, J., Lodder, E.M., Bakkers, J., Verkerk, A.O., Bezzina, C.R. (2019) Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I_K,ACh). Disease models & mechanisms. 12(7):

Monroe, G.R., van Eerde, A.M., Tessadori, F., Duran, K.J., Savelberg, S.M.C., van Alfen, J.C., Terhal, P.A., van der Crabben, S.N., Lichtenbelt, K.D., Fuchs, S.A., Gerrits, J., van Roosmalen, M.J., van Gassen, K.L., van Aalderen, M., Koot, B.G., Oostendorp, M., Duran, M., Visser, G., de Koning, T.J., Calì, F., Bosco, P., Geleijns, K., de Sain-van der Velden, M.G.M., Knoers, N.V., Bakkers, J., Verhoeven-Duif, N.M., van Haaften, G., Jans, J.J. (2019) Identification of human D lactate dehydrogenase deficiency. Nature communications. 10:1477

Chrispijn, N.D., Elurbe, D.M., Mickoleit, M., Aben, M., de Bakker, D.E.M., Andralojc, K.M., Huisken, J., Bakkers, J., Kamminga, L.M. (2019) Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development. Scientific Reports. 9:4327

Tessadori, F., Roessler, H.I., Savelberg, S.M.C., Chocron, S., Kamel, S.M., Duran, K.J., van Haelst, M.M., van Haaften, G., Bakkers, J. (2018) Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders. Disease models & mechanisms. 11(10):

van Opbergen, C.J.M., Koopman, C.D., Kok, B.J.M., Knöpfel, T., Renninger, S.L., Orger, M.B., Vos, M.A., van Veen, T.A.B., Bakkers, J., de Boer, T.P. (2018) Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis. Theranostics. 8:4750-4764

Burkhard, S.B., Bakkers, J. (2018) Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate. eLIFE. 7

Kievit, A., Tessadori, F., Douben, H., Jordens, I., Maurice, M., Hoogeboom, J., Hennekam, R., Nampoothiri, S., Kayserili, H., Castori, M., Whiteford, M., Motter, C., Melver, C., Cunningham, M., Hing, A., Kokitsu-Nakata, N.M., Vendramini-Pittoli, S., Richieri-Costa, A., Baas, A.F., Breugem, C.C., Duran, K., Massink, M., Derksen, P.W.B., van IJcken, W.F.J., van Unen, L., Santos-Simarro, F., Lapunzina, P., Gil-da Silva Lopes, V.L., Lustosa-Mendes, E., Krall, M., Slavotinek, A., Martinez-Glez, V., Bakkers, J., van Gassen, K.L.I., de Klein, A., van den Boogaard, M.H., van Haaften, G. (2018) Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome. European journal of human genetics : EJHG. 26(2):210-219

Sala, L., van Meer, B.J., Tertoolen, L.T., Bakkers, J., Bellin, M., Davis, R.P., Denning, C.N., Dieben, M.A., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E., Jongbloed, M.R., Kamel, S.M., Koopman, C.D., Lachaud, Q., Mannhardt, I., Mol, M.P., Mosqueira, D., Orlova, V.V., Passier, R., Ribeiro, M.C., Saleem, U., Smith, G., Burton, F.L.L., Mummery, C.L. (2017) MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo. Circulation research. 122(3):e5-e16

Tessadori, F., Giltay, J.C., Hurst, J.A., Massink, M.P., Duran, K., Vos, H.R., van Es, R.M., Scott, R.H., van Gassen, K.L.I., Bakkers, J., van Haaften, G. (2017) Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control. Nature Genetics. 49(11):1642-1646

Burkhard, S., van Eif, V., Garric, L., Christoffels, V.M., Bakkers, J. (2017) On the Evolution of the Cardiac Pacemaker. Journal of cardiovascular development and disease. 4(2)

De Angelis, J.E., Lagendijk, A.K., Chen, H., Tromp, A., Bower, N.I., Tunny, K.A., Brooks, A.J., Bakkers, J., Francois, M., Yap, A.S., Simons, C., Wicking, C., Hogan, B.M., Smith, K.A. (2017) Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover. Developmental Cell. 40:123-136

Paulussen, A.D., Steyls, A., Vanoevelen, J., van Tienen, F.H., Krapels, I.P., Claes, G.R., Chocron, S., Velter, C., Tan-Sindhunata, G.M., Lundin, C., Valenzuela, I., Nagy, B., Bache, I., Maroun, L.L., Avela, K., Brunner, H.G., Smeets, H.J., Bakkers, J., van den Wijngaard, A. (2016) Rare novel variants in the ZIC3 gene cause X-linked heterotaxy. European journal of human genetics : EJHG. 24(12):1783-1791

Han, M.K., Hoijman, E., Nöel, E., Garric, L., Bakkers, J., de Rooij, J. (2016) αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish. Biology Open. 5(10):1461-1472

Lodder, E.M., De Nittis, P., Koopman, C.D., Wiszniewski, W., Moura de Souza, C.F., Lahrouchi, N., Guex, N., Napolioni, V., Tessadori, F., Beekman, L., Nannenberg, E.A., Boualla, L., Blom, N.A., de Graaff, W., Kamermans, M., Cocciadiferro, D., Malerba, N., Mandriani, B., Akdemir, Z.H., Fish, R.J., Eldomery, M.K., Ratbi, I., Wilde, A.A., de Boer, T., Simonds, W.F., Neerman-Arbez, M., Sutton, V.R., Kok, F., Lupski, J.R., Reymond, A., Bezzina, C.R., Bakkers, J., Merla, G. (2016) GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability. American journal of human genetics. 99(3):704-10

Josifova, D.J., Monroe, G.R., Tessadori, F., de Graaff, E., van der Zwaag, B., Mehta, S.G., Harakalova, M., Duran, K.J., Savelberg, S.M., Nijman, I.J., Jungbluth, H., Hoogenraad, C.C., Bakkers, J., Knoers, N.V., Firth, H.V., Beales, P.L., van Haaften, G., van Haelst, M.M. (2016) Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity. Human molecular genetics. 25(11):2158-2167

San, B., Chrispijn, N.D., Wittkopp, N., van Heeringen, S.J., Lagendijk, A.K., Aben, M., Bakkers, J., Ketting, R.F., Kamminga, L.M. (2016) Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2. Scientific Reports. 6:24658

Noël, E.S., Momenah, T.S., Al-Dagriri, K., Al-Suwaid, A., Al-Shahrani, S., Jiang, H., Willekers, S., Oostveen, Y.Y., Chocron, S., Postma, A.V., Bhuiyan, Z.A., Bakkers, J. (2016) A zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals its Specific Role in Laterality Organ Function. Human Mutation. 37(2):194-200

Wu, C.C., Kruse, F., Vasudevarao, M.D., Junker, J.P., Zebrowski, D.C., Fischer, K., Noël, E.S., Grün, D., Berezikov, E., Engel, F.B., van Oudenaarden, A., Weidinger, G., Bakkers, J. (2016) Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration. Developmental Cell. 36(1):36-49

Kruse, F., Junker, J.P., van Oudenaarden, A., Bakkers, J. (2016) Tomo-seq: A method to obtain genome-wide expression data with spatial resolution. Methods in cell biology. 135:299-307

Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A.T., Wolfe, L.A., Tifft, C.J., Zerfas, P.M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M.G., Lee, C.R., Ferraz, V., da Silva, E.M., Stevens, C.A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B.P., Maduro, V., Dallapiccola, B., Ramos, F.J., Chung, H.B., Le Caignec, C., Martins, F., Jacyk, W.K., Mazzanti, L., Brunner, H.G., Bakkers, J., Lin, S., Malicdan, M.C., Boerkoel, C.F., Gahl, W.A., de Vries, B.B., van Haelst, M.M., Zenker, M., Markello, T.C. (2015) Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. American journal of human genetics. 97(1):99-110

Ramspacher, C., Steed, E., Boselli, F., Ferreira, R., Faggianelli, N., Roth, S., Spiegelhalter, C., Messaddeq, N., Trinh, L., Liebling, M., Chacko, N., Tessadori, F., Bakkers, J., Laporte, J., Hnia, K., Vermot, J. (2015) Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies. Cell Reports. 11:1564-76

Strate, I., Tessadori, F., Bakkers, J. (2015) Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling. Development (Cambridge, England). 142:1767-76

Duncker, D.J., Bakkers, J., Brundel, B.J., Robbins, J., Tardiff, J.C., Carrier, L. (2015) Animal- and In Silico Models for the study of Sarcomeric Cardiomyopathies. Cardiovascular research. 105(4):439-448

Tessadori, F., Noël, E.S., Rens, E.G., Magliozzi, R., Evers-van Gogh, I.J., Guardavaccaro, D., Merks, R.M., Bakkers, J. (2015) Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation. Developmental Cell. 32(5):631-9

Jiménez-Amilburu, V., Jong-Raadsen, S., Bakkers, J., Spaink, H.P., Marín-Juez, R. (2015) GLUT12 deficiency during early development results in heart failure and a diabetic phenotype. The Journal of endocrinology. 224(1):1-15

Chetaille, P., Preuss, C., Burkhard, S., Côté, J.M., Houde, C., Castilloux, J., Piché, J., Gosset, N., Leclerc, S., Wünnemann, F., Thibeault, M., Gagnon, C., Galli, A., Tuck, E., Hickson, G.R., Amine, N.E., Boufaied, I., Lemyre, E., de Santa Barbara, P., Faure, S., Jonzon, A., Cameron, M., Dietz, H.C., Gallo-McFarlane, E., Benson, D.W., Moreau, C., Labuda, D., FORGE Canada Consortium, Zhan, S.H., Shen, Y., Jomphe, M., Jones, S.J., Bakkers, J., Andelfinger, G. (2014) Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nature Genetics. 46(11):1245-9

Junker, J.P., Noël, E.S., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J., van Oudenaarden, A. (2014) Genome-wide RNA Tomography in the Zebrafish Embryo. Cell. 159:662-75

Bonetti, M., Paardekooper Overman, J., Tessadori, F., Noël, E., Bakkers, J., den Hertog, J. (2014) Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish. Development (Cambridge, England). 141:1961-70

Goudarzi, M., Strate, I., Paksa, A., Lagendijk, A.K., Bakkers, J., and Raz, E. (2013) On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling. Nature Genetics. 45(11):1264-1265

Postel, R., Margadant, C., Fischer, B., Kreft, M., Janssen, H., Secades, P., Zambruno, G., and Sonnenberg, A. (2013) Kindlin-1 mutant zebrafish as an in vivo model sytem to study adhesion mechanisms in the epidermis. The Journal of investigative dermatology. 133(9):2180-90

Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, L., Murphy, M.P., Medana, C., Stainier, D.Y., Bakkers, J., and Santoro, M.M. (2013) Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis. Cell. 152(3):504-518

Noël, E.S., Verhoeven, M., Lagendijk, A.K., Tessadori, F., Smith, K., Choorapoikayil, S., den Hertog, J., and Bakkers, J. (2013) A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nature communications. 4:2754

Hyde, A.S., Farmer, E., Easley, K.E., van Lammeren, K., Christoffels, V.M., Barycki, J.J., Bakkers, J., and Simpson, M.A. (2012) UDP-Glucose Dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly. The Journal of biological chemistry. 287(39):32708-32716

Goudarzi, M., Banisch, T.U., Mobin, M.B., Maghelli, N., Tarbashevich, K., Strate, I., van den Berg, J., Blaser, H., Bandemer, S., Paluch, E., Bakkers, J., Toli-Nørrelykke, I.M., and Raz, E. (2012) Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility. Developmental Cell. 23(1):210-218

Lagendijk, A.K., Moulton, J.D., and Bakkers, J. (2012) Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues. Biology Open. 1(6):566-569

de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., Strate, I., Smith, K., Lagendijk, A.K., Schilling, T.F., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M., and Bakkers, J. (2012) Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation. Circulation research. 110(4):578-587

Postel, R., and Sonnenberg, A. (2012) Carbonic anhydrase 5 regulates Acid-base homeostasis in zebrafish. PLoS One. 7(6):e39881

Tessadori, F., van Weerd, J.H., Burkhard, S.B., Verkerk, A.O., de Pater, E., Boukens, B.J., Vink, A., Christoffels, V.M., and Bakkers, J. (2012) Identification and functional characterization of cardiac pacemaker cells in zebrafish. PLoS One. 7(10):e47644

Smith, K.A., Lagendijk, A.K., Courtney, A.D., Chen, H., Paterson, S., Hogan, B.M., Wicking, C., and Bakkers, J. (2011) Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development (Cambridge, England). 138(19):4193-4198

Lagendijk, A.K., Goumans, M.J., Burkhard, S.B., and Bakkers, J. (2011) MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production. Circulation research. 109(6):649-57

Smith, K.A., Noël, E., Thurlings, I., Rehmann, H., Chocron, S., and Bakkers, J. (2011) Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish. PLoS Genetics. 7(9):e1002289

Ghani, S., Riemke, P., Schönheit, J., Lenze, D., Stumm, J., Hoogenkamp, M., Lagendijk, A., Heinz, S., Bonifer, C., Bakkers, J., Abdelilah-Seyfried, S., Hummel, M., and Rosenbauer, F. (2011) Macrophage development from hematopoietic stem cells requires PU.1 coordinated microRNA expression. Blood. 118(8):2275-84

Bakkers, J. (2011) Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovascular research. 91(2):279-88

Verhoeven, M.C., Haase, C., Christoffels, V.M., Weidinger, G., and Bakkers, J. (2011) Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2. Birth defects research. Part A, Clinical and molecular teratology. 91(6):435-40

Joziasse, I.C., Smith, K.A., Chocron, S., van Dinther, M., Guryev, V., van de Smagt, J.J., Cuppen, E., Ten Dijke, P., Mulder, B.J., Maslen, C.L., Reshey, B., Doevendans, P.A., and Bakkers, J. (2011) ALK2 mutation in a patient with Down's syndrome and a congenital heart defect. European journal of human genetics : EJHG. 19(4):389-93

Postel, R., Ketema, M., Kuikman, I., de Pereda, J.M., and Sonnenberg, A. (2011) Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish. Journal of Cell Science. 124(Pt 5):755-764

Mas, J.C., Noël, E.S., and Ober, E.A. (2011) Chromatin modification in zebrafish development. Methods in cell biology. 104:401-428

Noël, E.S., Reis, M.D., Arain, Z., and Ober, E.A. (2010) Analysis of the Albumin/alpha-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation. Gene expression patterns : GEP. 10(6):237-243

Beqqali, A., Monshouwer-Kloots, J., Monteiro, R., Welling, M., Bakkers, J., Ehler, E., Verkleij, A., Mummery, C., and Passier, R. (2010) CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. Journal of Cell Science. 123(Pt 7):1141-1150

Smith, K.A., Joziasse, I.C., Chocron, S., van Dinther, M., Guryev, V., Verhoeven, M.C., Rehmann, H., van der Smagt, J.J., Doevendans, P.A., Cuppen, E., Mulder, B.J., Ten Dijke, P., and Bakkers, J. (2009) Dominant-Negative ALK2 Allele Associates With Congenital Heart Defects. Circulation. 119(24):3062-3069

Bakkers, J., Verhoeven, M.C., and Abdelilah-Seyfried, S. (2009) Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis. Developmental Biology. 330(2):213-220

de Pater, E., Clijsters, L., Marques, S.R., Lin, Y.F., Garavito-Aguilar, Z.V., Yelon, D., and Bakkers, J. (2009) Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development (Cambridge, England). 136(10):1633-1641

Marques, I.J., Weiss, F.U., Vlecken, D.H., Nitsche, C., Bakkers, J., Lagendijk, A., Partecke, L.I., Heidecke, C.D., Lerch, M.M., and Bagowski, C.P. (2009) Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model. BMC cancer. 9:128

Noël, E.S., Casal-Sueiro, A., Busch-Nentwich, E., Verkade, H., Dong, P.D., Stemple, D.L., and Ober, E.A. (2008) Organ-specific requirements for Hdac1 in liver and pancreas formation. Developmental Biology. 322(2):237-250

Krens, S.F., He, S., Lamers, G.E., Meijer, A.H., Bakkers, J., Schmidt, T., Spaink, H.P., and Snaar-Jagalska, B.E. (2008) Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Developmental Biology. 319(2):370-383

Postel, R., Vakeel, P., Topczewski, J., Knöll, R., and Bakkers, J. (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Developmental Biology. 318(1):92-101

Monteiro, R., van Dinther, M., Bakkers, J., Wilkinson, R., Patient, R., Ten Dijke, P., and Mummery, C. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Developmental Biology. 315(1):55-71

Smith, K.A., Chocron, S., von der Hardt, S., de Pater, E., Soufan, A., Bussmann, J., Schulte-Merker, S., Hammerschmidt, M., and Bakkers, J. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Developmental Cell. 14(2):287-297

Bussmann, J., Bakkers, J., and Schulte-Merker, S. (2007) Early Endocardial Morphogenesis Requires Scl/Tal1. PLoS Genetics. 3(8):e140

Knöll, R., Postel, R., Wang, J., Krätzner, R., Hennecke, G., Vacaru, A.M., Vakeel, P., Schubert, C., Murthy, K., Rana, B.K., Kube, D., Knöll, G., Schäfer, K., Hayashi, T., Holm, T., Kimura, A., Schork, N., Toliat, M.R., Nürnberg, P., Schultheiss, H.P., Schaper, W., Schaper, J., Bos, E., den Hertog, J., van Eeden, F.J., Peters, P.J., Hasenfuss, G., Chien, K.R., and Bakkers, J. (2007) Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 116(5):515-525

Chocron, S., Verhoeven, M.C., Rentzsch, F., Hammerschmidt, M., and Bakkers, J. (2007) Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Developmental Biology. 305(2):577-588

von der Hardt, S., Bakkers, J., Inbal, A., Carvalho, L., Solnica-Krezel, L., Heisenberg, C.P., and Hammerschmidt, M. (2007) The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion. Current biology : CB. 17(6):475-487

van der Meer, D.L., Marques, I.J., Leito, J.T., Besser, J., Bakkers, J., Schoonheere, E., and Bagowski, C.P. (2006) Zebrafish cypher is important for somite formation and heart development. Developmental Biology. 299(2):356-372

Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H.,Poirier, F., and Griffioen, A.W. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proceedings of the National Academy of Sciences of the United States of America. 103(43):15975-15980

Bakkers, J., Camacho-Carvajal, M., Nowak, M., Kramer, C., Danger, B., and Hammerschmidt, M. (2005) Destabilization of DeltaNp63alpha by Nedd4-Mediated Ubiquitination and Ubc9-Mediated Sumoylation, and Its Implications on Dorsoventral Patterning of the Zebrafish Embryo. Cell cycle (Georgetown, Tex.). 4(6):790-800

Rentzsch, F., Bakkers, J., Kramer, C., and Hammerschmidt, M. (2004) Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition. Developmental dynamics : an official publication of the American Association of Anatomists. 231(4):750-757

Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M., and Birchmeier, W. (2004) Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions. Genes & Development. 18(18):2225-2230

Bakkers, J., Kramer, C., Pothof, J., Quaedvlieg, N.E., Spaink, H.P., and Hammerschmidt, M. (2004) Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development (Cambridge, England). 131(3):525-537

Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kühl, M., Schaeffer, H.J., Huelsken, J., Behrens, J., Hammerschmidt, M. and Birchmeier, W. (2002) The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the betacatenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes & Development. 16(16):2073-2084

Bakkers, J., Hild, M., Kramer, C., Furutani-Seiki, M., and Hammerschmidt, M. (2002) Zebrafish Delta Np63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. Developmental Cell. 2(5):617-627

Lele, Z., Bakkers, J., and Hammerschmidt, M. (2001) Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations. Genesis (New York, N.Y. : 2000). 30(3):190-194

Bakkers, J.P.W.M. (2000) Chitin oligosaccharides in zebrafish development : investigations at the molecular and cellular level. Ph.D. Thesis. :149p

Kamst, E., Bakkers, J., Quaedvlieg, N.E., Pilling, J., Kijne, J.W., Lugtenberg, B.J., and Spaink, H.P. (1999) Chitin oligosaccharide synthesis by rhizobia and zebrafish embryos starts by glycosyl transfer to O4 of the reducing-terminal residue. Biochemistry. 13:4045-4052

Bakkers, J., Kijne, J.W. and Spaink, H.P. (1999) Function of chitin oligosaccharides in plant and animal development. In Chitin and chitinases, R.A.A. Muzzarelli and P. Jollès, eds. Basel/Switzerland: Birkhäuser Verlag. :69-81

Semino, C.E., Allende, M.L., Bakkers, J., Sapink, H.P., and Robbins, P.P. (1998) Expression of Rhizobium Chitin Oligosaccharide Fucosyltransferase in zebrafish embryos disrupts normal development. Annals of the New York Academy of Sciences. 842:49-54

Bakkers, J., Semino, C.E., Stroband, H., Kijne, J.W., Robbins, P.W., and Spaink, H.P. (1997) An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish. Proceedings of the National Academy of Sciences of the United States of America. 94(15):7982-7986