ZFIN ID: ZDB-LAB-021218-1
Lawson Lab
PI/Director: Lawson, Nathan
Contact Person: Lawson, Nathan
Email: nathan.lawson@umassmed.edu
URL: http://lawsonlab.umassmed.edu/
Address: Program in Gene Function and Expression University of Massachusetts Medical School Lazare Research Building, Room 617 364 Plantation Street Worcester, MA 01605 USA
Country: United States
Phone: Office: (508) 856-1177, Lab: (508) 856-2269/2605
Fax: (508) 856-5460
Line Designation: um


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 47 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS
Shin, Masahiro Post-Doc Moore, John Graduate Student Sheppard, Sarah Graduate Student
Villefranc, Jacque Graduate Student Kourkoulis, George D. Research Staff Lakshmanan, Abirami Research Staff
Smith, Tom Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Lawson, N.D. (2017) A New Conserved Player in Lymphatic Morphogenesis. Circulation research. 120:1216-1218
Anelli, V., Villefranc, J.A., Chhangawala, S., Martinez-McFaline, R., Riva, E., Nguyen, A., Verma, A., Bareja, R., Chen, Z., Scognamiglio, T., Elemento, O., Houvras, Y. (2017) Oncogenic BRAF disrupts thyroid morphogenesis and function via Twist expression. eLIFE. 6
Matsuoka, R.L., Marass, M., Avdesh, A., Helker, C.S., Maischein, H.M., Grosse, A.S., Kaur, H., Lawson, N.D., Herzog, W., Stainier, D.Y. (2016) Radial glia regulate vascular patterning around the developing spinal cord. eLIFE. 5
Moore, J.C., Tang, Q., Yordán, N.T., Moore, F.E., Garcia, E.G., Lobbardi, R., Ramakrishnan, A., Marvin, D.L., Anselmo, A., Sadreyev, R.I., Langenau, D.M. (2016) Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish. The Journal of experimental medicine. 213(12):2575-2589
Shin, M., Male, I., Beane, T.J., Villefranc, J.A., Kok, F.O., Zhu, L.J., Lawson, N.D. (2016) Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development (Cambridge, England). 143(20):3785-3795
Shin, M., Beane, T., Quillien, A., Male, I., Zhu, L.J., Lawson, N.D. (2016) Vegfa signals through ERK to promote angiogenesis, but not artery differentiation. Development (Cambridge, England). 143(20):3796-3805
Moore, F.E., Garcia, E.G., Lobbardi, R., Jain, E., Tang, Q., Moore, J.C., Cortes, M., Molodtsov, A., Kasheta, M., Luo, C.C., Garcia, A.J., Mylvaganam, R., Yoder, J.A., Blackburn, J.S., Sadreyev, R.I., Ceol, C.J., North, T.E., Langenau, D.M. (2016) Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. The Journal of experimental medicine. 213(6):979-92
Moore, J.C., Langenau, D.M. (2016) Allograft Cancer Cell Transplantation in Zebrafish. Advances in experimental medicine and biology. 916:265-87
Au, S.H., Storey, B.D., Moore, J.C., Tang, Q., Chen, Y.L., Javaid, S., Sarioglu, A.F., Sullivan, R., Madden, M.W., O'Keefe, R., Haber, D.A., Maheswaran, S., Langenau, D.M., Stott, S.L., Toner, M. (2016) Clusters of circulating tumor cells traverse capillary-sized vessels. Proceedings of the National Academy of Sciences of the United States of America. 113(18):4947-52
Tang, Q., Moore, J.C., Ignatius, M.S., Tenente, I.M., Hayes, M.N., Garcia, E.G., Torres Yordán, N., Bourque, C., He, S., Blackburn, J.S., Look, A.T., Houvras, Y., Langenau, D.M. (2016) Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish. Nature communications. 7:10358
Shmukler, B.E., Lawson, N.D., Paw, B.H., Alper, S.L. (2016) Authors' response to "Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia'". Haematologica. 101:e39
Lawson, N.D. (2015) Reverse Genetics in Zebrafish: Mutants, Morphants, and Moving Forward. Trends in cell biology. 26(2):77-9
Hen, G., Nicenboim, J., Mayseless, O., Asaf, L., Shin, M., Busolin, G., Hofi, R., Almog, G., Tiso, N., Lawson, N.D., Yaniv, K. (2015) Venous-derived angioblasts generate organ-specific vessels during embryonic development. Development (Cambridge, England). 142(24):4266-78
Shmukler, B.E., Huston, N.C., Thon, J.N., Ni, C.W., Kourkoulis, G., Lawson, N.D., Paw, B.H., Alper, S.L. (2015) Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia. Haematologica. 100(12):e483-5
Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61
Butko, E., Distel, M., Pouget, C., Weijts, B., Kobayashi, I., Ng, K., Mosimann, C., Poulain, F.E., McPherson, A., Ni, C.W., Stachura, D.L., Del Cid, N., Espín-Palazón, R., Lawson, N.D., Dorsky, R., Clements, W.K., Traver, D. (2015) Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (Cambridge, England). 142:1050-61
Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
Tenente, I.M., Tang, Q., Moore, J.C., Langenau, D.M. (2014) Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish. Journal of visualized experiments : JoVE. (94)
Tang, Q., Abdelfattah, N.S., Blackburn, J.S., Moore, J.C., Martinez, S.A., Moore, F.E., Lobbardi, R., Tenente, I.M., Ignatius, M.S., Berman, J.N., Liwski, R.S., Houvras, Y., Langenau, D.M. (2014) Optimized cell transplantation using adult rag2 mutant zebrafish. Nature Methods. 11(8):821-4
Carroll, K.J., Esain, V., Garnaas, M.K., Cortes, M., Dovey, M.C., Nissim, S., Frechette, G.M., Liu, S.Y., Kwan, W., Cutting, C.C., Harris, J.M., Gorelick, D.A., Halpern, M.E., Lawson, N.D., Goessling, W., North, T.E. (2014) Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental Cell. 29:437-53
Quillien, A., Moore, J.C., Shin, M., Siekmann, A.F., Smith, T., Pan, L., Moens, C.B., Parsons, M.J., Lawson, N.D. (2014) Distinct Notch signaling outputs pattern the developing arterial system. Development (Cambridge, England). 141:1544-52
Kok, F.O., Gupta, A., Lawson, N.D., and Wolfe, S.A. (2014) Construction and application of site-specific artificial nucleases for targeted gene editing. Meth. Mol. Biol.. 1101:267-303
Moore, J.C., Sheppard, S., Shestopalov, I.A., Chen, J.K., and Lawson, N. (2013) Post-transcriptional mechanisms contribute to Etv2 repression during vascular development. Developmental Biology. 384(1):128-40
Villefranc, J.A., Nicoli, S., Bentley, K., Jeltsch, M., Zarkada, G., Moore, J.C., Gerhardt, H., Alitalo, K., and Lawson, N.D. (2013) A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development (Cambridge, England). 140(7):1497-1506
Gupta, A., Hall, V.L., Kok, F.O., Shin, M., McNulty, J.C., Lawson, N.D., and Wolfe, S.A. (2013) Targeted Chromosomal Deletions and Inversions in Zebrafish. Genome research. 23(6):1008-17
Shin, J., Padmanabhan, A., de Groh, E.D., Lee, J.S., Haidar, S., Dahlberg, S., Guo, F., He, S., Wolman, M.A., Granato, M., Lawson, N.D., Wolfe, S.A., Kim, S.H., Solnica-Krezel, L., Kanki, J.P., Ligon, K.L., Epstein, J.A., and Look, A.T. (2012) Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Disease models & mechanisms. 5(6):881-894
Gupta, A., Christensen, R.G., Rayla, A.L., Lakshmanan, A., Stormo, G.D., and Wolfe, S.A. (2012) An optimized two-finger archive for ZFN-mediated gene targeting. Nature Methods. 9(6):588-590
Nicoli, S., Knyphausen, C.P., Zhu, L.J., Lakshmanan, A., and Lawson, N.D. (2012) miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development. Developmental Cell. 22(2):418-429
Delaval, B., Covassin, L., Lawson, N.D., and Doxsey, S. (2011) Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish. Cell cycle (Georgetown, Tex.). 10(22):3964-3972
Cheung, I.D., Bagnat, M., Ma, T.P., Datta, A., Evason, K., Moore, J.C., Lawson, N.D., Mostov, K.E., Moens, C.B., and Stainier, D.Y. (2011) Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. Developmental Biology. 361(1):68-78
Zhu, C., Smith, T., McNulty, J., Rayla, A.L., Lakshmanan, A., Siekmann, A.F., Buffardi, M., Meng, X., Shin, J., Padmanabhan, A., Cifuentes, D., Giraldez, A.J., Look, A.T., Epstein, J.A., Lawson, N.D., and Wolfe, S.A. (2011) Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development (Cambridge, England). 138(20):4555-4564
Lawson, N.D., and Wolfe, S.A. (2011) Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish. Developmental Cell. 21(1):48-64
Clements, W.K., Kim, A.D., Ong, K.G., Moore, J.C., Lawson, N.D., and Traver, D. (2011) A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 474(7350):220-224
Quillien, A., Blanco-Sanchez, B., Halluin, C., Moore, J.C., Lawson, N.D., Blader, P., and Cau, E. (2011) BMP signaling orchestrates photoreceptor specification in the zebrafish pineal gland in collaboration with Notch. Development (Cambridge, England). 138(11):2293-2302
Delaval, B., Bright, A., Lawson, N.D., and Doxsey, S. (2011) The cilia protein IFT88 is required for spindle orientation in mitosis. Nature Cell Biology. 13(4):461-468
Aday, A.W., Zhu, L.J., Lakshmanan, A., Wang, J., and Lawson, N.D. (2011) Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites. Developmental Biology. 357(2):450-62
Gupta, A., Meng, X., Zhu, L.J., Lawson, N.D., and Wolfe, S.A. (2011) Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases. Nucleic acids research. 39(1):381-392
Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone, M., Mariggi, G., Bruyere, F., Cotelli, F., Kerjaschki, D., Noel, A., Foidart, J.M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P., and Dewerchin, M. (2010) Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 30(9):1695-1702
Chapouton, P., Skupien, P., Hesl, B., Coolen, M., Moore, J.C., Madelaine, R., Kremmer, E., Faus-Kessler, T., Blader, P., Lawson, N.D., and Bally-Cuif, L. (2010) Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(23):7961-7974
Cifuentes, D., Xue, H., Taylor, D.W., Patnode, H., Mishima, Y., Cheloufim, S., Ma, E., Mane, S., Hannon, G.J., Lawson, N.D., Wolfe, S.A., and Giraldez, A.J. (2010) A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (New York, N.Y.). 328(5986):1694-1698
Nicoli, S., Standley, C., Walker, P., Hurlstone, A., Fogarty, K.E., and Lawson, N.D. (2010) MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 464(7292):1196-1200
Lorent, K., Moore, J.C., Siekmann, A.F., Lawson, N., and Pack, M. (2010) Reiterative use of the notch signal during zebrafish intrahepatic biliary development. Developmental dynamics : an official publication of the American Association of Anatomists. 239(3):855-864
Padmanabhan, A., Lee, J.S., Ismat, F.A., Lu, M.M., Lawson, N.D., Kanki, J.P., Look, A.T., and Epstein, J.A. (2009) Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proc. Natl. Acad. Sci. USA. 106(52):22305-22310
Amigo, J.D., Ackermann, G.E., Cope, J.J., Yu, M., Cooney, J.D., Ma, D., Langer, N.B., Shafizadeh, E., Shaw, G.C., Horsley, W., Trede, N.S., Davidson, A.J., Barut, B.A., Zhou, Y., Wojiski, S.A., Traver, D., Moran, T.B., Kourkoulis, G., Hsu, K., Kanki, J.P., Shah, D.I., Lin, H.F., Handin, R.I., Cantor, A.B., and Paw, B.H. (2009) The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood.. 114(21):4654-4663
Parsons, M.J., Pisharath, H., Yusuff, S., Moore, J.C., Siekmann, A.F., Lawson, N., and Leach, S.D. (2009) Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mechanisms of Development. 126(10):898-912
Siekmann, A.F., Standley, C., Fogarty, K.E., Wolfe, S.A., and Lawson, N.D. (2009) Chemokine signaling guides regional patterning of the first embryonic artery. Genes and Development. 23(19):2272-2277
Covassin, L.D., Siekmann, A.F., Kacergis, M.C., Laver, E., Moore, J.C., Villefranc, J.A., Weinstein, B.M., and Lawson, N.D. (2009) A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Developmental Biology. 329(2):212-226
Meng, X., Noyes, M.B., Zhu, L.J., Lawson, N.D., and Wolfe, S.A. (2008) Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat. Biotechnol.. 26(6):695-701
Bussmann, J., Lawson, N., Zon, L., Schulte-Merker, S., and Zebrafish Nomenclature Committee. (2008) Zebrafish VEGF receptors: a guideline to nomenclature. PLoS Genetics. 4(5):e1000064
Hart, D.O., Raha, T., Lawson, N.D., and Green, M.R. (2007) Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Nature. 450(7172):1082-1085
Villefranc, J.A., Amigo, J., and Lawson, N.D. (2007) Gateway compatible vectors for analysis of gene function in the zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 236(11):3077-3087
Buchner, D.A., Su, F., Yamaoka, J.S., Kamei, M., Shavit, J.A., Barthel, L.K., McGee, B., Amigo, J.D., Kim, S., Hanosh, A.W., Jagadeeswaran, P., Goldman, D., Lawson, N.D., Raymond, P.A., Weinstein, B.M., Ginsburg, D., and Lyons, S.E. (2007) pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc. Natl. Acad. Sci. USA. 104(35):13996-140001
Pham, V.N., Lawson, N.D., Mugford, J.W., Dye, L., Castranova, D., Lo, B., and Weinstein, B.M. (2007) Combinatorial function of ETS transcription factors in the developing vasculature. Developmental Biology. 303(2):772-783
Siekmann, A.F., and Lawson, N.D. (2007) Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature. 445(7129):781-784
Covassin, L., Amigo, J.D., Suzuki, K., Teplyuk, V., Straubhaar, J., and Lawson, N.D. (2006) Global analysis of hematopoietic and vascular endothelial gene expression by tissue specific microarray profiling in zebrafish. Developmental Biology. 299(2):551-562
Alt, B., Elsalini, O.A., Schrumpf, P., Haufs, N., Lawson, N.D., Schwabe, G.C., Mundlos, S., Gruters, A., Krude, H., and Rohr, K.B. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development (Cambridge, England). 133(19):3797-3804
Chervenak, A.P., Basu, P., Shin, M., Redmond, L.C., Sheng, G., and Lloyd, J.A. (2006) Identification, characterization, and expression pattern of the chicken EKLF gene. Developmental dynamics : an official publication of the American Association of Anatomists. 235(7):1933-1940
Covassin, L.D., Villefranc, J.A., Kacergis, M.C., Weinstein, B.M., and Lawson, N.D. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc. Natl. Acad. Sci. USA. 103(17):6554-6559
Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., and Hukriede, N.A. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc. Natl. Acad. Sci. USA. 102(51):18473-18478
Crump, J.G., Maves, L., Lawson, N.D., Weinstein, B.M., and Kimmel, C.B. (2004) An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development (Cambridge, England). 131(22):5703-5716
Huang, C., Lawson, N.D., Weinstein, B.M., and Johnson, S.L. (2003) reg6 is required for branching morphogenesis during blood vessel regeneration in zebrafish caudal fins. Developmental Biology. 264(1):263-274
Isogai, S., Lawson, N.D., Torrealday, S., Horiguchi, M., and Weinstein, B.M. (2003) Angiogenic network formation in the developing vertebrate trunk. Development (Cambridge, England). 130(21):5281-5290
Lawson, N.D., Mugford, J.W., Diamond, B.A., and Weinstein, B.M. (2003) phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes and Development. 17(11):1346-1351
Lawson, N.D. and Weinstein, B.M. (2002) Arteries and veins: making a difference with zebrafish. Nature reviews. Genetics. 3(9):674-682
Lawson, N.D. and Weinstein, B.M. (2002) In vivo imaging of embryonic vascular development using transgenic zebrafish. Developmental Biology. 248(2):307-318
Lawson, N.D., Vogel, A.M., and Weinstein, B.M. (2002) sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Developmental Cell. 3(1):127-136
Roman, B.L., Pham, V., Lawson, N.D., Kulik, M., Childs, S., Lekven, A.C., Garrity, D.M., Moon, R.T., Fishman, M.C., Lechleider, R.J., and Weinstein, B.M. (2002) Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (Cambridge, England). 129(12):3009-3019
Lyons, S.E., Lawson, N.D., Lei, L., Bennett, P.E., Weinstein, B.M., and Liu, P.P. (2002) A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proc. Natl. Acad. Sci. USA. 99(8):5454-5459
Weinstein, B.M. and Lawson, N.D. (2002) Arteries, veins, Notch, and VEGF. Cold Spring Harbor symposia on quantitative biology. 67:155-162
Lawson, N.D., Scheer, N., Pham, V.N., Kim, C.-H., Chitnis, A.B., Campos-Ortega, J.A., and Weinstein, B.M. (2001) Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development (Cambridge, England). 128(19):3675-3683
Lyons, S.E., Lawson, N.D., Bennett, P.J., Weinstein, B.M., and Liu, P.P. (2000) Nonsense mutation in gata1 identified in the "bloodless" zebrafish vlad tepes. Blood.. 96(11):2400