ZFIN ID: ZDB-LAB-000623-1
Shuo Lin Lab
PI/Director: Lin, Shuo
Contact Person: Lin, Shuo
Email: shuolin@ucla.edu
URL: http://www.mcdb.ucla.edu/Research/ShuoLin/index.html
Address: Department of Molecular, Cell and Developmental Biology University of California, Los Angeles 4325 Life Sciences Building 621 Charles E. Young Drive South P.O. Box 951606 Los Angeles, CA 90095-1606 USA
Country: United States
Phone: 310-267-4972
Fax: (310) 206-3987
Line Designation: la

Show first 50 of 67 genomic features

Our long term goal is to understand vertebrate development at a genetic and molecular level and to develop zebrafish models for human genetic disorders. We are working to define the genetic pathways underlying hematopoiesis with a special interest in identifying those factors that mediate the initial determination and proliferation of hematopoietic stem cells. A saturation mutagensis screen, recently completed for zebrafish, allowed for the isolation of many mutants defective in blood formation. We have obtained these mutants and are analyzing them to identify those that many be defective in stem cell formation or proliferation. We have generated transgeneic fish that express green fluorescent protien as a reporter gene specifically in the hemapoietic progenitor cells. These fish make it possible to visualize the origin and migration of the earliest hematopoietic stem cells in a live embryo, and to purify them for in vitro studies. Using this system, coupled to genetic analysis of embryonic blood mutations, we have developed approaches that allow rapid detection of novel genes that are expressed in hematopoietic progenitor cells during embryogenesis. Given that the expression pattern and sequences of many hematopoietic genes are well conserved between fish, mice, and humans, our studies should ultimately lead to a better understanding of the molecular and genetic bases underlying mammalian hematopoietic development.

Bentolila, Laurent Research Staff Danilova, Nadia Research Staff Desai, Sharina Palencia Research Staff
Gomez, Gustavo Research Staff Huang, Haigen Research Staff Jiang, Hong Research Staff
Liu, Anqi Research Staff Rios, Yesenia Research Staff Shu, Xiaodong Research Staff
Song, Jianbo Research Staff Tehrani, Zahra Research Staff Yang, Zhongan Research Staff
Zhang, Lijun Research Staff Zhao, Yan Research Staff

Wilkes, M.C., Siva, K., Varetti, G., Mercado, J., Wentworth, E.P., Perez, C.A., Saxena, M., Kam, S., Kapur, S., Chen, J., Narla, A., Glader, B., Lin, S., Serrano, M., Flygare, J., Sakamoto, K.M. (2020) Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a. Experimental hematology. 91:65-77
Chen, C., Lu, M., Lin, S., Qin, W. (2020) The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond-Blackfan anemia. Cell Death & Disease. 11:135
Bai, H., Liu, L., An, K., Lu, X., Harrison, M., Zhao, Y., Yan, R., Lu, Z., Li, S., Lin, S., Liang, F., Qin, W. (2020) CRISPR/Cas9-mediated precise genome modification by a long ssDNA template in zebrafish. BMC Genomics. 21:67
Chen, C., Huang, H., Yan, R., Lin, S., Qin, W. (2019) Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia. G3 (Bethesda). 9(12):4149-4157
Youn, M., Huang, H., Chen, C., Kam, S., Wilkes, M.C., Chae, H.D., Sridhar, K.J., Greenberg, P.L., Glader, B., Narla, A., Lin, S., Sakamoto, K.M. (2019) MMP9 inhibition increases erythropoiesis in RPS14-deficient del(5q) MDS models through suppression of TGF-β pathways. Blood advances. 3:2751-2763
Qin, W., Lu, X., Liu, Y., Bai, H., Li, S., Lin, S. (2018) Precise A•T to G•C base editing in the zebrafish genome. BMC Biology. 16:139
Qin, W., Lu, X., Lin, S. (2018) Programmable base editing in zebrafish using a modified CRISPR-Cas9 system. Methods (San Diego, Calif.). 150:19-23
Fornabaio, G., Barnhill, R.L., Lugassy, C., Bentolila, L.A., Cassoux, N., Roman-Roman, S., Alsafadi, S., Del Bene, F. (2018) Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model. Scientific Reports. 8:10448
Zhao, S., Xia, J., Wu, X., Zhang, L., Wang, P., Wang, H., Li, H., Wang, X., Chen, Y., Agnetti, J., Li, Y., Pei, D., Shu, X. (2018) Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish. Nature communications. 9:2639
Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
Davis, J.A., Koenig, A.L., Lubert, A., Chestnut, B., Liu, F., Desai, S.P., Winkler, T., Pociute, K., Choi, K., Sumanas, S. (2018) ETS transcription factor Etsrp / Etv2 is required for lymphangiogenesis and directly regulates vegfr3 / flt4 expression. Developmental Biology. 440(1):40-52
Danilova, N., Wilkes, M., Bibikova, E., Youn, M.Y., Sakamoto, K.M., Lin, S. (2018) Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. Scientific Reports. 8:5165
Lu, X., Liu, Y., Yan, G., Li, S., Qin, W., Lin, S. (2018) Optimized Target-AID system efficiently induces single base changes in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 45(4):215-217
Feng, Z., Nam, S., Hamouri, F., Aujard, I., Ducos, B., Vriz, S., Volovitch, M., Jullien, L., Lin, S., Weiss, S., Bensimon, D. (2017) Optical Control of Tumor Induction in the Zebrafish. Scientific Reports. 7:9195
Zhang, Y., Qin, W., Lu, X., Xu, J., Huang, H., Bai, H., Li, S., Lin, S. (2017) Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. Nature communications. 8:118
Zhang, Y., Huang, H., Zhao, G., Yokoyama, T., Vega, H., Huang, Y., Sood, R., Bishop, K., Maduro, V., Accardi, J., Toro, C., Boerkoel, C.F., Lyons, K., Gahl, W.A., Duan, X., Malicdan, M.C., Lin, S. (2017) ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genetics. 13:e1006481
Pei, S., Liu, L., Zhong, Z., Wang, H., Lin, S., Shang, J. (2016) Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine. Scientific Reports. 6:33822
Feng, Y., Chen, C., Han, Y., Chen, Z., Lu, X., Liang, F., Li, S., Qin, W., Lin, S. (2016) Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9. G3 (Bethesda). 6(8):2517-21
Zhao, H., Osborne, O.J., Lin, S., Ji, Z., Damoiseux, R., Wang, Y., Nel, A.E., Lin, S. (2016) Lanthanide Hydroxide Nanoparticles Induce Angiogenesis via ROS-Sensitive Signaling. Small (Weinheim an der Bergstrasse, Germany). 12(32):4404-11
Ear, J., Hsueh, J., Nguyen, M., Zhang, Q., Sung, V., Chopra, R., Sakamoto, K.M., Lin, S. (2016) A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure. Journal of genetics and genomics = Yi chuan xue bao. 43(5):307-18
Wu, W., Hai, Y., Chen, L., Liu, R.J., Han, Y.X., Li, W.H., Li, S., Lin, S., Wu, X.R. (2016) Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity. Pharmacology research & perspectives. 4:e00212
Huang, P., Xiao, A., Tong, X., Lin, S., Zhang, B. (2016) Targeted Mutagenesis in Zebrafish by TALENs. Methods in molecular biology (Clifton, N.J.). 1338:191-206
Zhang, Y., Huang, H., Zhang, B., Lin, S. (2016) TALEN- and CRISPR-enhanced DNA homologous recombination for gene editing in zebrafish. Methods in cell biology. 135:107-20
Zhao, H., Huang, H., Lin, S. (2016) Chemical approaches to angiogenesis in development and regeneration. Methods in cell biology. 134:369-76
Veldman, M.B., Rios-Galdamez, Y., Lu, X.H., Gu, X., Qin, W., Li, S., Yang, X.W., Lin, S. (2015) The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model. Molecular neurodegeneration. 10:67
Osborne, O.J., Lin, S., Chang, C.H., Ji, Z., Yu, X., Wang, X., Lin, S., Xia, T., Nel, A.E. (2015) Organ-Specific and Size-Dependent Ag Nanoparticle Toxicity in Gills and Intestines of Adult Zebrafish. ACS nano. 9(10):9573-84
Liang, F., Han, Y., Gao, H., Xin, S., Chen, S., Wang, N., Qin, W., Zhong, H., Lin, S., Yao, X., Li, S. (2015) Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways. Scientific Reports. 5:14468
Ear, J., Huang, H., Wilson, T., Tehrani, Z., Lindgren, A., Sung, V., Laadem, A., Daniel, T.O., Chopra, R., Lin, S. (2015) RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1. Blood. 126(7):880-90
Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A.T., Wolfe, L.A., Tifft, C.J., Zerfas, P.M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M.G., Lee, C.R., Ferraz, V., da Silva, E.M., Stevens, C.A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B.P., Maduro, V., Dallapiccola, B., Ramos, F.J., Chung, H.B., Le Caignec, C., Martins, F., Jacyk, W.K., Mazzanti, L., Brunner, H.G., Bakkers, J., Lin, S., Malicdan, M.C., Boerkoel, C.F., Gahl, W.A., de Vries, B.B., van Haelst, M.M., Zenker, M., Markello, T.C. (2015) Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. American journal of human genetics. 97(1):99-110
Ye, B.X., Deng, X., Shao, L.D., Lu, Y., Xiao, R., Liu, Y.J., Jin, Y., Xie, Y.Y., Zhao, Y., Luo, L.F., Ma, S., Gao, M., Zhang, L.R., He, J., Zhang, W.N., Chen, Y., Xia, C.F., Deng, M., Liu, T.X., Zhao, Q.S., Chen, S.J., Chen, Z. (2015) Vibsanin B Preferentially Targets HSP90β, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). 194(9):4489-97
Lindgren, A.G., Veldman, M.B., Lin, S. (2015) ETV2 expression increases the efficiency of primitive endothelial cell derivation from human embryonic stem cells. Cell regeneration (London, England). 4:1
Bibikova, E., Youn, M.Y., Danilova, N., Ono-Uruga, Y., Konto-Ghiorghi, Y., Ochoa, R., Narla, A., Glader, B., Lin, S., Sakamoto, K.M. (2014) TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors. Blood. 124(25):3791-8
Veldman, M.B., Lin, S. (2014) Stem Cells on Fire: Inflammatory Signaling in HSC Emergence. Developmental Cell. 31:517-518
Yuan, Y., Zhang, Y., Yao, S., Shi, H., Huang, X., Li, Y., Wei, Y., Lin, S. (2014) The translation initiation factor Eif3i upregulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis. The Journal of biological chemistry. 289(41):28310-23
Hüsken, U., Stickney, H.L., Gestri, G., Bianco, I.H., Faro, A., Young, R.M., Roussigne, M., Hawkins, T.A., Beretta, C.A., Brinkmann, I., Paolini, A., Jacinto, R., Albadri, S., Dreosti, E., Tsalavouta, M., Schwarz, Q., Cavodeassi, F., Barth, A.K., Wen, L., Zhang, B., Blader, P., Yaksi, E., Poggi, L., Zigman, M., Lin, S., Wilson, S.W., Carl, M. (2014) Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons. Current biology : CB. 24(19):2217-27
Zhang, Y., Ear, J., Yang, Z., Morimoto, K., Zhang, B., Lin, S. (2014) Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19. Cell Death & Disease. 5:e1352
Danilova, N., Bibikova, E., Covey, T.M., Nathanson, D., Dimitrova, E., Konto, Y., Lindgren, A., Glader, B., Radu, C.G., Sakamoto, K.M., Lin, S. (2014) The role of DNA damage response in zebrafish and cellular models of Diamond Blackfan Anemia. Disease models & mechanisms. 7(7):895-905
Qin, W., Chen, Z., Zhang, Y., Yan, R., Yan, G., Li, S., Zhong, H., Lin, S. (2014) Nom1 Mediates Pancreas Development by Regulating Ribosome Biogenesis in Zebrafish. PLoS One. 9:e100796
Carayannopoulos, M.O., Xiong, F., Jensen, P., Rios-Galdamez, Y., Huang, H., Lin, S., Devaskar, S.U. (2014) GLUT3 gene expression is critical for embryonic growth, brain development and survival. Molecular genetics and metabolism. 111:477-83
Yang, F., Xiong, J., Jia, X.E., Gu, Z.H., Shi, J.Y., Zhao, Y., Li, J.M., Chen, S.J., Zhao, W.L. (2014) GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression. PLoS One. 9:e89302
Tong, X., Zu, Y., Li, Z., Li, W., Ying, L., Yang, J., Wang, X., He, S., Liu, D., Zhu, Z., Chen, J., Lin, S., and Zhang, B. (2014) Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish. Nature communications. 5:3153
Lin, S., Zhao, Y., Ji, Z., Ear, J., Chang, C.H., Zhang, H., Low-Kam, C., Yamada, K., Meng, H., Wang, X., Liu, R., Pokhrel, S., Mädler, L., Damoiseaux, R., Xia, T., Godwin, H.A., Lin, S., and Nel, A.E. (2013) Metal Oxides: Zebrafish High-Throughput Screening to Study the Impact of Dissolvable Metal Oxide Nanoparticles on the Hatching Enzyme, ZHE1 (Small 9-10/2013). Small (Weinheim an der Bergstrasse, Germany). 9(9-10):1775
Xia, Z., Tong, X., Liang, F., Zhang, Y., Kuok, C., Zhang, Y., Liu, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish. Developmental Biology. 381(1):83-96
Ren, G., Li, S., Zhong, H., and Lin, S. (2013) Zebrafish tyrosine hydroxylase 2 Gene Encodes Tryptophan Hydroxylase. The Journal of biological chemistry. 288(31):22451-9
Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic acids research. 41(14):e141
Wang, L., Liu, T., Xu, L., Gao, Y., Wei, Y., Duan, C., Chen, G.Q., Lin, S., Patient, R., Zhang, B., Hong, D., and Liu, F. (2013) Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 122(3):367-75
Zhao, Y., and Lin, S. (2013) Essential Role of Sh3gl3 for Vascular Lumen Maintenance in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 33(6):1280-6
Lin, S., Zhao, Y., Ji, Z., Ear, J., Chang, C.H., Zhang, H., Low-Kam, C., Yamada, K., Meng, H., Wang, X., Liu, R., Pokhrel, S., Mädler, L., Damoiseaux, R., Xia, T., Godwin, H.A., Lin, S., and Nel, A.E. (2013) Zebrafish High-Throughput Screening to Study the Impact of Dissolvable Metal Oxide Nanoparticles on the Hatching Enzyme, ZHE1. Small (Weinheim an der Bergstrasse, Germany). 9(9-10):1776-85
Lin, S., Zhao, Y., Nel, A.E., and Lin, S. (2013) Zebrafish: An In Vivo Model for Nano EHS Studies. Small (Weinheim an der Bergstrasse, Germany). 9(9-10):1608-18
Kohli, V., Schumacher, J.A., Desai, S.P., Rehn, K., and Sumanas, S. (2013) Arterial and venous progenitors of the major axial vessels originate at distinct locations. Developmental Cell. 25(2):196-206
Lu, J., Xin, S., Meng, H., Veldman, M., Schoenfeld, D., Che, C., Yan, R., Zhong, H., Li, S., and Lin, S. (2013) A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay. PLoS One. 8(4):e53317
Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
Zu, Y., Tong, X., Wang, Z., Liu, D., Pan, R., Li, Z., Hu, Y., Luo, Z., Huang, P., Wu, Q., Zhu, Z., Zhang, B., and Lin, S. (2013) TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nature Methods. 10(4):329-31
Tong, X., Xia, Z., Zu, Y., Telfer, H., Hu, J., Yu, J., Liu, H., Zhang, Q., Sodmergen, D., Lin, S., and Zhang, B. (2013) Ngs (notochord granular surface) encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. The Journal of biological chemistry. 288(4):2711-2720
Huang, P., Xu, L., Liang, W., Tam, C.I., Zhang, Y., Qi, F., Zhu, Z., Lin, S., and Zhang, B. (2013) Genomic deletion induced by Tol2 transposon excision in zebrafish. Nucleic acids research. 41(2):e36
Liu, N., Li, Z., Pei, D., and Shu, X. (2013) Zfyve9a regulates the proliferation of hepatic cells during zebrafish embryogenesis. The International journal of developmental biology. 57(9-10):773-778
Veldman, M.B., Zhao, C., Gomez, G.A., Lindgren, A.G., Huang, H., Yang, H., Yao, S., Martin, B.L., Kimelman, D., and Lin, S. (2013) Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor etv2. PLoS Biology. 11(6):e1001590
Yuan, Y., Zhao, Y., Xin, S., Wu, N., Wen, J., Li, S., Chen, L., Wei, Y., Yang, H., and Lin, S. (2013) A Novel PEGylated Liposome-Encapsulated SANT75 Suppresses Tumor Growth through Inhibiting Hedgehog Signaling Pathway. PLoS One. 8(4):e60266
Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.
Huang, H., Lindgren, A., Wu, X., Liu, N.A., and Lin, S. (2012) High-throughput screening for bioactive molecules using primary cell culture of transgenic zebrafish embryos. Cell Reports. 2(3):695-704
Huang, P., Zhu, Z., Lin, S., and Zhang, B. (2012) Reverse genetic approaches in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):421-433
Xu, L., Feng, Z., Sinha, D., Ducos, B., Ebenstein, Y., Tadmor, A.D., Gauron, C., Le Saux, T., Lin, S., Weiss, S., Vriz, S., Jullien, L., and Bensimon, D. (2012) Spatiotemporal manipulation of retinoic acid activity in zebrafish hindbrain development via photo-isomerization. Development (Cambridge, England). 139(18):3355-3362
Chen, L., Ren, X., Liang, F., Li, S., Zhong, H., and Lin, S. (2012) Characterization of two novel small molecules targeting melanocyte development in zebrafish embryogenesis. Pigment cell & melanoma research. 25(4):446-453
Yin, W., Liu, D., Liu, N., Xu, L., Li, S., Lin, S., Shu, X., Pei, D. (2012) SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1. Cell regeneration (London, England). 1:4
Xu, L., Yin, W., Xia, J., Peng, M., Li, S., Lin, S., Pei, A., and Shum, X. (2012) An anti-apoptotic role of SNX7 is required for liver development in zebrafish. Hepatology (Baltimore, Md.). 55(6):1985-1993
Chen, Y., Wu, B., Xu, L., Li, H., Xia, J., Yin, W., Li, Z., Li, S., Lin, S., Shu, X., and Pei, D. (2012) A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Research. 22(2):333-345
Veldman, M.B., and Lin, S. (2012) Etsrp/Etv2 Is Directly Regulated by Foxc1a/b in the Zebrafish Angioblast. Circulation research. 110(2):220-229
Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
Liu, H., Gomez, G., Lin, S., Lin, S., and Lin, C. (2012) Optogenetic control of transcription in zebrafish. PLoS One. 7(11):e50738
Liu, R., Lin, S., Rallo, R., Zhao, Y., Damoiseaux, R., Xia, T., Lin, S., Nel, A., and Cohen, Y. (2012) Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials. PLoS One. 7(4):e35014
Zhang, Y., Morimoto, K., Danilova, N., Zhang, B., and Lin, S. (2012) Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing. PLoS One. 7(1):e30188
Tehrani, Z., and Lin, S. (2011) Endocrine pancreas development in zebrafish. Cell cycle (Georgetown, Tex.). 10(20):3466-3472
Lin, S., Zhao, Y., Xia, T., Meng, H., Ji, Z., Liu, R., George, S., Xiong, S., Wang, X., Zhang, H., Pokhrel, S., Mädler, L., Damoiseaux, R., Lin, S., and Nel, A.E. (2011) High Content Screening in Zebrafish Speeds up Hazard Ranking of Transition Metal Oxide Nanoparticles. ACS nano. 5(9):7284-95
Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.
Huang, P., Xiao, A., Zhou, M., Zhu, Z., Lin, S., and Zhang, B. (2011) Heritable gene targeting in zebrafish using customized TALENs. Nat. Biotechnol.. 29(8):699-700
Zhao, C., Yang, H., Shi, H., Wang, X., Chen, X., Yuan, Y., Lin, S., and Wei, Y. (2011) Distinct Contributions of Angiogenesis and Vascular Co-option during the Initiation of Primary Microtumors and Micrometastases. Carcinogenesis. 32(8):1143-50
Zhong, H., Wang, D., Wang, N., Rios, Y., Huang, H., Li, S., Wu, X., and Lin, S. (2011) Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity. Cell Research. 21(7):1080-7
Liu, N.A., Jiang, H., Ben-Shlomo, A., Wawrowsky, K., Fan, X.M., Lin, S., and Melmed, S. (2011) Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 108(20):8414-8419
George, S., Xia, T., Rallo, R., Zhao, Y., Ji, Z., Lin, S., Wang, X., Zhang, H., France, B., Schoenfeld, D., Damoiseaux, R., Liu, R., Lin, S., Bradley, K.A., Cohen, Y., and Nel, A.E. (2011) Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials. ACS nano. 5(3):1805-17
Xia, T., Zhao, Y., Sager, T., George, S., Pokhrel, S., Li, N., Schoenfeld, D., Meng, H., Lin, S., Wang, X., Wang, M., Ji, Z., Zink, J.I., Madler, L., Castranova, V., Lin, S., and Nel, A.E. (2011) Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos. ACS nano. 5(2):1223-1235
Huang, W., Deng, Y., Dong, W., Yuan, W., Wan, Y., Mo, X., Li, Y., Wang, Z., Wang, Y., Ocorr, K., Zhang, B., Lin, S., and Wu, X. (2011) The effect of excess expression of GFP in a novel heart-specific green fluorescence zebrafish regulated by nppa enhancer at early embryonic development. Molecular biology reports. 38(2):793-799
Tehrani, Z., and Lin, S. (2011) Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development. Development (Cambridge, England). 138(4):631-640
Ríos, Y., Melmed, S., Lin, S., and Liu, N.A. (2011) Zebrafish usp39 Mutation Leads to rb1 mRNA Splicing Defect and Pituitary Lineage Expansion. PLoS Genetics. 7(1):e1001271
Bai, X., Yang, Z., Jiang, H., Lin, S., and Zon, L.I. (2011) Genetic suppressor screens in haploids. Methods in cell biology. 104:129-136
Chou, S.W., Hwang, P., Gomez, G., Fernando, C.A., West, M.C., Pollock, L.M., Lin-Jones, J., Burnside, B., and McDermott, B.M. (2011) Fascin 2b Is a Component of Stereocilia that Lengthens Actin-Based Protrusions. PLoS One. 6(4):e14807
Danilova, N., Sakamoto, K.M., and Lin, S. (2011) Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects. British journal of haematology. 152(2):217-228
Gao, W., Xu, L., Guan, R., Liu, X., Han, Y., Wu, Q., Xiao, Y., Qi, F., Zhu, Z., Lin, S., and Zhang, B. (2011) Wdr18 Is Required for Kupffer's Vesicle Formation and Regulation of Body Asymmetry in Zebrafish. PLoS One. 6(8):e23386
Ren, G., Xin, S., Li, S., Zhong, H., and Lin, S. (2011) Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish. PLoS One. 6(6):e20630
Zhao, C., Wang, X., Zhao, Y., Li, Z., Lin, S., Wei, Y., and Yang, H. (2011) A novel xenograft model in zebrafish for high-resolution investigating dynamics of neovascularization in tumors. PLoS One. 6(7):e21768
Zhong, H., and Lin, S. (2011) Chemical screening with zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 716:193-205
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Zhong, H., Xin, S., Zhao, Y., Lu, J., Li, S., Gong, J., Yang, Z., and Lin, S. (2010) Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish. Molecular Biosystems. 6(8):1463-1468
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