ZFIN Image: Wang et al., 2024, FIGURE 6

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Figure Caption

FIGURE 6

ISO deteriorates cardiac function in HET(52del) adults. (A) ISO treatment results in reduced cardiac output in WT and HET(52del), but not in KO(52del), compared to vehicle‐treated controls. (B) ISO treatment leads to reduced stroke volume in HET(52del), not in WT and KO(52del) compared to vehicle‐treated controls. (C, D) ISO treatment has no significant effect on heart rate (C) or ejection fraction (D) in the three genotypic groups compared to respective vehicle controls. (E, F) ISO treatment leads to reduced end‐diastolic (E) and end‐systolic area (F) in HET(52del), not in WT and KO(52del) compared to vehicle‐treated controls. WT, vehicle n = 10, ISO n = 8; HET(52del), vehicle n = 10, ISO n = 7; KO(52del), vehicle n = 9, ISO n = 8. Data are presented as mean ± SD. Two‐sample t‐test. * p < 0.05, ** p < 0.01, *** p < 0.001.

Acknowledgments

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