ZFIN Image: Bustad et al., 2024, FIGURE 5

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FIGURE 5

Azithromycin and aminoglycosides do not interact antagonistically in bacteria. (A) depicts ototoxic interactions in zebrafish as measured by PEPITA, while the subsequent three panels depict interactions as measured by checkerboard assay with the given bacterium, respectively: (B)E. coli, (C)M. abscessus, and (D)S. aureus. The x-axis quantifies the windowed excess over Bliss metric (wEOB), which measures drug interactions with negative numbers indicating antagonism and positive numbers indicating synergy. The y-axis contains 5 aminoglycoside antibiotics. None of the measured combinations yield a consistently antagonistic interaction in terms of the bacterial growth inhibition achieved, in contrast with the significant antagonistic protection AZM confers against damage induced by all of these drugs.

Acknowledgments

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