ZFIN Image: Fu et al., 2023, Fig. 8

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Figure Caption

Fig. 8 Working model of Fst function as a molecular barrier of LR asymmetry in the LPM (Zebrafish, Chick, and Frog) and Epithalamus (zebrafish). Briefly, Nodal induced fst to express bilaterally on both sides of the developing embryos. Under the function of LRO, Nodal signaling is weaker in the right LPM where it is completely blocked by Fst, while stronger Nodal in the left LPM can overcome the inhibition of Fst and spread from PA regions, though still restricted as it does so by Fst. In zebrafish, Activin could induce ndr2/lefty1 expression in the forebrain, but this is then suppressed by Fst at an early stage. When Spaw arrives, as emanated from the left LPM, this helps overcome the suppression of Fst so that ndr2/lefty1 can be turned on in the left side of the forebrain.

Acknowledgments

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