ZFIN Image: Uribe et al., 2023, Fig. 6

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Figure Caption

Fig. 6 MM-201 does not alter aminoglycoside-induced threshold shifts in mice. Animals were treated with 0, 0.3, or 1 µg/ml MM-201 with or without kanamycin. Threshold shift was calculated as the post-treatment minus the pre-treatment threshold for each animal. There is a significant effect of both treatment (F_5,112=16.77, p<0.0001) and frequency (F_3,112=5.847, p = 0.001) (2-way ANOVA), but this effect manifests as differences between saline-treated controls and each of the other groups. Each black dot denotes the threshold shift for each individual animal. N = 5–6 animals/group (2–3 per sex) and error bars represent ± s.e.m.

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Reprinted from Hearing Research, 434, Uribe, P.M., Hudson, A.M., Lockard, G., Jiang, M., Harding, J., Steyger, P.S., Coffin, A.B., Hepatocyte growth factor mimetic confers protection from aminoglycoside-induced hair cell death in vitro, 108786108786, Copyright (2023) with permission from Elsevier. Full text @ Hear. Res.