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Figure 8
A model for RhoA-dependent migration of muSCs. Migratory muSCs show a RhoA-dependent cell cortex contractility that drives nuclear positioning and cell migration. In an absence of ROCK activity caused by Y-27632, focal adhesions are smaller, less clustered and less polarized along the axis of cell migration leading to reduced adhesion to the extracellular matrix. This correlates with an increased differentiation potential and more rapid migratory behaviour of muSCs.
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