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Fig. 1
tet2-mutant haematopoietic stem and progenitor cells are hypersensitive to selinexor and eltanexor. (A) Embryos with the indicated genotypes were treated with either dimethylsulfoxide (DMSO), selinexor or eltanexor from 1–5 days post fertilisation (dpf). Whole-mount in situ hybridisation was performed using a riboprobe for c-myb at 5 dpf (overall magnification: 5×). Insets in each of the images show a magnified image of the caudal haematopoietic tissue (CHT) region (magnification in the inset: 11.25×). (B) Quantification of cells exhibiting c-myb expression in the CHT region shown in panel A.
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Full text @ Br. J. Haematol.