ZFIN Image: Krylov et al., 2023, Figure 4

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Figure Caption

Figure 4

Investigation of phagocytosis and proliferation by Müller glia following photoreceptor ablation. (A–F) Micrograph images of Müller glia (Gfap-positive; green) detecting proliferative marker PCNA (pink) and photoreceptor debris (red) across three photoreceptor ablation paradigms. (G,I,K) Quantifications of the percentage of debris-containing, and proliferating Müller glia. (H,J,L) Cell counts presented as proportions of debris-containing Müller glia in PCNA+ and PCNA- populations. (M) UMAP plot of quiescent (dotted line) and proliferative (solid line) Müller glia clusters expressing glula and pcna, respectively, (N) from Lws2 ablation scRNAseq sample. (O) Violin Plots of the expression of phagocytosis associated markers rac1a, mertka, and plxnb1b. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001.

Acknowledgments

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