Gene expression modules in activated Müller glia following photoreceptor ablation. (A) UMAP plot of integrated Lws2 and Sws2-ablation scRNA-seq samples. (B) Differences in clusters between photoreceptor ablation samples is associated with differentiating Müller glia-derived progenitor cells. (C,D) Trajectory of integrated dataset along pseudotime from quiescent (glula) to late proliferating (cdk1) Müller glia. (E) Heatmap showing the top 40 differentially expressed genes along pseudotime from left to right, grouped together by gene modules. (F,G) Expression plots of differentially expressed markers along pseudotime.
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