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Fig. 8 Schematic diagram showing the working model depicting what is currently understood for the role of Shoc2 embryonic development. Shoc2 amplifies and modulates ERK1/2 signaling during early stages of NC development. Shoc2 loss alters expression of key transcription factors essential for NCCs specification, migration and differentiation. Defects in early stages of NC development lead to aberrant expression of downstream effector genes, including proteins regulating homeostasis and remodeling of ECM, ultimately leading to the profound defects in multiple NCC derivatives.
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Reprinted from Developmental Biology, 492, Norcross, R.G., Abdelmoti, L., Rouchka, E.C., Andreeva, K., Tussey, O., Landestoy, D., Galperin, E., Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix, 156-171, Copyright (2022) with permission from Elsevier. Full text @ Dev. Biol.