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Figure 8
EGFR signaling is required for regeneration.
(A) Immunofluorescence showing mCherry (magenta) and PCNA (green) signal for regenerating animals at 3 dpa.RT after chemical treatments. Inhibition of EGFR, PI3K, and mTOR dramatically reduces both cell proliferation and changes in cell morphology. Number of animals resembling the representative image are in white in the lower right corner of each image. Scale bars: 50 μm. (B) Illustration comparing mammalian and zebrafish liver architecture and cell types. (C) Model of biliary-mediated hepatocyte regeneration and the requirement for active EGFR, PI3K, and mTOR signaling.
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