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Fig. 4 Figure 4. Transcriptional activity of h, m, zf, and xPPARγ in response to synthetic hPPARα and hLXR ligands. Results are expressed as a percentage of the maximum luciferase activity induced by 1 μM rosiglitazone (HG5LN-hPPARγ, HG5LN-mPPARγ), 10 μM GW 3965 (HG5LN-zfPPARγ), or 10 μM rosiglitazone (HG5LN-xPPARγ). Agonist hPPARα ligand GW 7647 (A) tested in agonist assay; antagonist hPPARα ligand GW 6471 (B) tested in antagonist assay; and agonist hLXR ligand GW 3965 tested in agonist assays (C). Error bars represent standard deviations.
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