ZFIN Image: Spelat et al., 2022, Fig. 5

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Fig. 5

Membrane N-glycan profile of regenerating zebrafish heart established by LC-MS/MS revealed increased sialylation and a reduction in high mannose structures during the inflammatory phase.

a Comparison of N-glycan types (complex, high mannose and hybrid) and sialylation between sham and the different regeneration phases (2, 7 and 14 dpci). The inflammatory phase (2 dpci) showed a 6% increase in sialylated glycans and a 5% decrease in high mannose structures compared to sham. b Summary of the main changes in N-glycans features (sialylated hybrid and complex type increase/decrease, non-sialylated hydrid and complex type increase/decrease, high mannose-type increase/decrease) showing some of the corresponding structures. c Heatmap displaying time-specific relative quantification of neutral, and d sialylated N-glycans. Color intensity represents the relative abundance expressed as a percentage. e Extracted ion chromatography (EIC) showing the most abundant membrane N-glycans present in zebrafish heart. Results deriving from samples pooling of six animals are shown (n = 6 animals per group).

Acknowledgments

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