Image
|
Figure Caption
Fig. 7.
PRC2 and H3K27me3 mediate the Top2a-dependent gene regulation.
(A) TOP2A binding peaks substantially overlap with EZH2, SUZ12, and H3K27me3. (B) Among all EZH2, SUZ12, and H3K27me3 binding peaks, those that overlap with TOP2A are more enriched for autism and its comorbidities risk genes and can4Dn but not for can4Up and neurodegenerative disorder risk gene sets. Significance was calculated by paired t test. NDD, neurodegenerative disorders. SFARI_1/2, high-confidence SFARI genes with a gene score of 1 or 2. (C) Working model for how PRC2 and H3K27me3 mediate the Top2a-dependent gene regulation and social development. **P < 0.01 and ****P < 0.0001.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Sci Adv