|
Fig. 11 (A) EPI-X4 JM#21 is active in a mouse model of atopic dermatitis. Ears of BALB/c mice were applied every two days with mock or MC903 (2.5 nmol/ear). (B) EPI-X4 JM#21 (400 nmol/ear), AMD3100 (315 nmol/ear), dexamethasone (Dexa, 20 nmol/ear) or ethanol (EtOH) were applied topically daily. Representative photographs of ears are taken at day 12. Ear thickness (C) and the inflammatory score (D) were determined daily. Mice were used for MC903 (n = 8–16) and controls (n = 4–7). Data shown are mean ± SEM. ####P ≤ 0.0001 compared to CTR + EtOH group, and ∗∗∗P ≤ 0.01, ∗∗∗∗P ≤ 0.0001 compared to MC903 + EtOH group.