ZFIN Image: He et al., 2022, Figure 7

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Figure Caption

Figure 7

Effective in vivo GFP silencing mediated by the DOTAP/MC3 LNP/siRNA system (10D/40M) in Tg (kdrl: eGFP) zebrafish. Confocal microscopy images of GFP (scale bar: 200 µm) in (A) dmLNP containing siRNA_GFP or siRNA_ctrl (dmLNP/siRNA_GFP vs. dmLNP/siRNA_ctrl); (B) mLNP containing siRNA_GFP or siRNA_ctrl (mLNP/siRNA_GFP vs. mLNP/siRNA_ctrl); (C) Untreated group. (D) Quantification of GFP fluorescence in entire images by ImageJ (n = 7). The data represent the mean ± SD. *** p < 0.001according to one-way ANOVA, Tukey’s multiple comparisons test. Scale bar of (A–C): 200 µm.

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