ZFIN Image: Nakonieczna et al., 2022, Fig. 10

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Figure Caption

Fig. 10

(A) The absorbance of different doses of coptisine (11) (12.5, 25, 62.5, 125, 187.5 or 250 µg/mL) (39.02, 78.04, 195.12, 390.24, 585.37 or 780.49 µM) by larval zebrafish after 95 h of incubation, n = 4–6 samples/group, n = 100 larvae per sample. Dose-dependent effect of coptisine (11) on (B) hatching rate (%) of 72 and 96 hpf-old larvae, n = 20–24/group; (C) swim bladder inflation at 96 hpf, n = 30–34/group; (D) yolk sac necrosis at 96 hpf, n = 30–34/group; (E) touch-evoked response at 96 hpf, n = 30–34/group; (F) representative images of larvae exposed to coptisine (11) (12.5, 125 or 250 µg/mL) (39.02, 390.24 or 780.49 µM). All experiments were done in triplicates and data were pooled together (** p < 0.01; *** p < 0.001 vs. control group, Fisher’s exact test). COP-coptisine (11), hpf—hours post-fertilization. Scale bar 1 mm.

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