ZFIN Image: Moret et al., 2022, Fig. 5

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Figure Caption

Fig. 5

Toxicity and activity of DTX-loaded NPs in the zebrafish embryo xenograft model. A Timeline of the in vivo experiments. The microscopy image shows 3 embryos xenografted with KB cells (red fluorescence). B Toxicity of NPs in xenograft zebrafish embryos injected with DTX and DTX-loaded NPs ([DTX] = 2.5 ng/animal) after 6 days from the treatment. C Tumor volume reduction after 6 days from the treatment with DTX-loaded NPs ([DTX] = 2.5 ng/animal). Total tumor fluorescence quantified from images. ^§p < 0.05; ^§§p < 0.01; ^§§§p < 0.001 vs. ctrl; *p < 0.001 vs. free DTX. D Representative images of KB cells xenotransplanted in the embryo yolks. Scale bars: 500 μm

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