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Fig. 4
α-KG treatment in T-ALL cells increases DNA demethylation in a concentration-dependent manner. (A,B) 5hmC staining in MOLT3 (A) and PEER (B) cells after 24 and 48 h of treatment with 0, 3.5, or 7 mM of α-KG. DAPI (blue) counterstaining indicates the intranuclear location. The quantification of relative 5hmC fluorescence (red) is presented as the mean ± s.e.m., and an unpaired two-tailed t-test is used for statistical analysis. Scale bar = 10 μm. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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