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Fig. 1
FIGURE 1. Protein alignment and mutation sites in human and zebrafish SUMF1/FGE. Human and zebrafish protein sequences share 59.94% sequence identify, increasing to 71.9% over the PFAM domain for FGE-sulfatase activity (yellow highlight). The viral insertion in the sumf1_la015919Tg line occurs in exon one and results in a premature stop codon (blue label). The point mutation in the sumf1_sa31531 line occurs in exon 2 and results in a nonsense mutation and premature stop codon (purple label).
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