ZFIN Image: Lin et al., 2022, FIG 5

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FIG 5

WhiB4 binds dosS in hypoxic culture upon aeration. (A) Overlap of the WhiB4 binding sites in bacteria grown under different conditions. (B) WhiB4 binding sites at the dosR-dosS locus. Binding sites 1 and 2 were detected in cultures at 0.5 h postaeration. Binding sites 1 and 3 were detected in hypoxic cultures without aeration. The numbers in black are the genome coordinates of the indicated genes, and the numbers in red indicate the binding site of WhiB4. (C) Model for the WhiB4-mediated regulation of the DosR regulon. Upon aeration of hypoxic cultures, WhiB4 binds directly to dosS and inhibits its expression, and consequently the expression of the DosR regulon is repressed.

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