ZFIN Image: Habicher et al., 2022, Fig 3

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Fig 3

Severe malformation in the adult head skeleton.

Alterations in the morphology of the ceratohyal and urohyal were magnified in all four genotypes (for spatial position of elements in the zebrafish head, see S1 movie). Adult csgalnact1a^-/- ; chsy1^-/- zebrafish displayed gross malformations and reduced body size compared to control and csgalnact1a^-/- adults (A). 3D reconstructions of all genotypes showed that no bone structures were missing (B,D,F,H and S1–S4 Figs). However, shorter and misshaped elements were common in csgalnact1a^-/- (F) and csgalnact1a^-/- ; chsy1^-/- fish (H), while the chsy1^-/- skeletal phenotype (D) was milder, compared to the control (B). The differences in morphological integrity of skeletal elements was evident from magnifications, for example the boundary between the anterior and the posterior part (arrow) of the ceratohyal and posterior edge (*) and of the urohyal (C,E,G,I and S5-12).

Acknowledgments

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