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Figure 3

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ZDB-IMAGE-220131-145
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Figures for Bu et al., 2021
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Figure 3

A screen of compounds targeting 7 known CM pathways identified therapeutic compounds for VEC.

(A and B) Representative images and percentage of vmhcle13/e13 mutant fish with the indicated phenotypes after administration of the compounds or DMSO control at 5 dpf. Black stars indicate severe edema, and red stars indicate mild edema. It is anticipated that 25% of vmhcle13/+ incross offspring are homozygous vmhcle13/e13, which manifest severe pericardial edema (black stars). Administration of 5 different drugs reduced the percentage of vmhcle13/e13 mutants with edema to less than 20%; 3 of these drugs reduced the percentage with edema with statistical significance (P < 0.05). n = 84–122; χ2 test; scale bar: 500 μm. (C) Percent FS of the vmhcle13/e13 mutants after administration of the compounds compared to WT control at 5 dpf. n = 8; data are presented as the mean ± SD; 1-way ANOVA.

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