ZFIN Image: Wang et al., 2021, Figure 5

Image

Figure Caption

Figure 5

Inhibition of BMP and Notch signaling pathways differentially suppresses FUCCI expression. (A) Time-lapse images of Tg(vmhc:mCherry-NTR; myl7:mAG-zGeminin) hearts showed differential patterns of zGem+ CMs in ablated, DAPT-treated ablated and DM-treated ablated groups at 0-72 hpt. Scale bars, 50 µm. hpt, hours post MTZ-treatment; CM, cardiomyocyte; DM, dorsomorphin. (B, C) Quantification of zGem+ CM numbers in the whole heart (B) or in the atrium only (C) of ablated and DAPT-treated ablated groups at 24, 48 and 72 hpt. Mean + SD, N=8-15 for each group, Student's t-test, *, P <0.05, ***, P < 0.001, ****, P < 0.0001. (D, E) Quantification of zGem+ CM numbers in the whole heart (D) or in the atrium only (E) of ablated and DM-treated ablated groups at 24, 48 and 72 hpt. Mean + SD, N=6-13 for each group, Student's t-test, *, P <0.05, **, P < 0.01.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Biol. Sci.