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Figure 2—figure supplement 1. MITF CUT&RUN peak distribution and motifs.

(a) Bar graph displaying the percentage of genome wide MITF CUT&RUN peak distribution. (b, c) Motif analysis of MITF peaks on reduced and induced DEGs in ΔMITF-X6 vs. EV-SkMel28 cells using MEMEChIP. E-value is a measure of the expected number of motifs with the same size occurring in the random database. (d) View of MITF CUT and RUN in SkMEL28 (rep1 and rep2), MITF ChIP-seq in COLO829 cells (Webster et al., 2014), and HA-MITF ChIP-Seq in 501Mel (Laurette et al., 2015) loaded in IGV genome browser indicating MITF peaks in CDH1, CDH2, ZEB1, SNAI2 and SOX2.

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