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FIGURE 8
Summary of the larval zebrafish immune response to heart injury. Following laser heart injury in the early phase (0–2 hpi), immune cells resident to nearby pericardial tissues are recruited to the ventricle. At the same time, distal neutrophils and macrophages begin to egress from the CHT into the vascular system. Distal macrophages and neutrophils subsequently utilize blood and lymphatic vessels to migrate to the injured heart, joining locally recruited immune cells during the peak phase (6–24 hpi). The majority of these cells actively crawl along the abluminal surface of vessels, but some also roll and flow along the inside of vessels. The resolution phase is characterized by reverse migration of immune cells to adjacent tissues (> 6 hpi). Created with