ZFIN Image: Gallardo-Fuentes et al., 2020, FIGURE 2

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Figure Caption

FIGURE 2

Zebrafish and human p63 binding sites (BSs) drive similar expression patterns. (A) Table showing the overlap in expression patterns driven by cis-regulatory element (CRE) pairs from zebrafish and human, as detected in zebrafish transgenic reporter assays. Note that all BS pairs share at least three expression domains in both species. (B) Genome tracks from zebrafish (top) and human (bottom) showing p63 ChIP-seq signal, p63 peaks, ENSEMBL genes, and vertebrate sequence conservation. The selected p63 BSs for transgenic reporter assays, which are located upstream to the myh9a/MYH9 genes, are highlighted in light orange. (C) Transgenic zebrafish embryos at different stages showing the green fluorescent protein (GFP) expression pattern driven by the enhancers highlighted in (B). Tissues expressing GFP are pointed using white arrowheads. s, skin; ysl, yolk syncytial layer; pfb, pectoral fin bud.

Acknowledgments

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