ZFIN Image: Bertolini et al., 2019, Figure 3

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Figure Caption

Figure 3

Distal Anchors Connected by Sox2-Dependent Interactions to Genes Important in Neural Development and Disease

(A and B) Sox2-dependent ChIA-PET interactions (TR1) between two different genes (Sox4, A; Zbtb18, B) and distal regions overlapping previously characterized “VISTA” enhancers (Visel et al., 2009); SOX2 ChIP-seq peaks (present paper), lacZ-stained transgenic embryos (from https://enhancer.lbl.gov), and evolutionary conservation (ECR browser).

(C and D) Sox2-dependent interactions (wTR1, wTR2, wTR3, mTR1, mTR2, and mTR3) involving Gpr56 (C) and Arid1a (D), two genes whose human homologs are involved in neurodevelopmental brain disease.

See also Figure S5 and Tables S5 and S6.

Acknowledgments

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