ZFIN Image: Zheng et al., 2015, Fig. 2

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Figure Caption

Fig. 2

Measurement of In Vivo Anti-infective Activities of Drugs

(A) M. marinum-infected zebrafish larvae (n = 10) in the presence of each test drug (3 μM). Left: Fluorescence intensity of GFPmut3-expressing bacteria in larvae 5 days after treatment (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001; error bars represent the standard deviation). Right: larval survival during the treatment period.

(B) M. marinum-infected zebrafish adults (n = 20) treated once with each test drug (10 μl of 5 μM). Left: Pathological section of the infected area of randomly selected adults 10 days after treatment. The arrow indicates the existing or obliterated bacterial burden (red). Scale bar, 100 μm. Right: Adult survival during the treatment period.

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Acknowledgments

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