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Fig. 8
28 hpf RA-deficient embryos exhibit increased Cxcl12b chemokine signaling pathway component gene expression.
(A-C') Representative flat-mount 28 hpf embryos following in situ hybridization analyses. Lateral view of gene expression in the dorsal aorta region of the trunk is shown with anterior to the left. Compared to DMSO-treated controls (A, B, C), embryos treated with 2.5 μM DEAB exhibit strongly increased levels of dorsal aorta cxcr4a (A'), and cxcl12b (B') gene expression, and upregulated somitic meox1 expression (C').
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