ZFIN Image: Zhao et al., 2016, Fig. 2

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Figure Caption

Fig. 2

Solid endothelial cords are recruited into the endogenous microtumors in zebrafish.

(A,B) Hollow host vessels (inset box) at the margin of endogenous rhabdomyosarcoma (RMS) and solid endothelial cords (green) at the interior of RMS microtumor (red), in a 25d Tg(fli1a1:GFP) zebrafish. (C) 3D projection and optical section images of the interior RMS microtumor (box in C) showing the tumor-recruited solid angiogenic sprouts. (D,E) Endogenous glioma and blood vessels in the head of 9d zebrafish. Hollow host vessels (panel i) in head (H) is morphologically distinct to solid endothelial sprouts or separate ECs in glioma (panels ii, iii, iv). (F) Quantitative analysis of tumor neovessels with or without blood-perfusion in RMS and glioma (n = 3 for RMS, n = 4 for glioma, error bars show SEM). For experimental outline and the resulting RMS and glioma bearing zebrafish, see Fig. S4.

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