|ZFIN ID: ZDB-IMAGE-150512-1|
OA1 MOs reduce melanosome number at 2dpf without affecting melanosome size. (A–D) Contrast-enhanced images of zebrafish eye cross-sections highlighting only electron-dense melanin. Images are shown from (A,B) control and (C,D) OA1 MO-treated zebrafish. KD, knockdown. Scale bars: 20µm. (E) At 2dpf there is a significant reduction in melanin area between controls and OA1 MO-treated zebrafish. By 5dpf, the OA1 MO appears to be less effective, resulting in no significant difference in melanin area between controls and OA1 MO-treated animals. (F) The OA1 MO had no apparent effect on melanosome diameter at 2 and 5dpf. Results show the mean±s.e.m.; *P<0.05 (Student′s t-test).
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