ZFIN Image: Ruyra et al., 2013, Fig. 1

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Figure Caption

Fig. 1

Characterization of liposomal formulations.

(A) Representative Cryo-TEM image of DLPC/Chol/Cholesteryl/PEG₆₀₀-Chol (563.56160.5) liposomes extruded through a 200 nm pore size membrane. (B) Confocal fluorescence image of a single liposome tagged on its lipid bilayer with Marina Blue-DHPE (blue) and its corresponding fluorescence intensity profile. (C) Confocal fluorescence image of a single Marina Blue-labeled liposome containing AlexaFluor594-labeled LPS (red) and their corresponding fluorescence intensity profiles. (D) Confocal fluorescence image of a single Marina Blue-labeled liposome containing fluorescein-labeled poly (I:C) and their corresponding fluorescence intensity profiles. (E) Schematic representation of the liposomal IS-cocktail (NL_c) showing the presence of both encapsulated LPS (red) and poly (I:C) (green) in the lipidic bilayer of liposomes. (F) Confocal fluorescence image of a single liposome containing both fluorescein-labeled poly (I:C) (green) and AlexaFluor594-labeled LPS (red) and their corresponding fluorescence intensity profiles.

Acknowledgments

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