ZFIN Image: Kujawski et al., 2014, Fig. 3

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Figure Caption

Fig. 3

Treatment with FK506 Enhances Outgrowth of the Developing Juvenile Fin

(A) Caudal fin of a juvenile fish at 30 days postfertilization (dpf).

(B) Fin of the same 65 dpf fish in (A) after DMSO treatment for 35 days.

(C) Adult fin of fish 118 dpf after DMSO treatment for 88 days.

(D) Caudal fin of a juvenile fish 30 dpf before FK506 treatment.

(E) Fin of same fish 65 dpf after FK506 treatment for 35 days.

(F) Caudal fin of fish 118 dpf after FK506 treatment for 88 days.

(G) Body length measurements of treated juvenile fish during growth. Regression lines for slopes are 0.0025 fin/body ratio per day for FK506 treated and 0.00018 fin/body ratio per day for DMSO control.

(H) Graph shows growth as fin-to-body ratio of treatment groups.

Scale bars, 500 μm (A–F). In (G) and (H), data are represented as mean ± SD from two experiments each containing six or more animals.

Acknowledgments

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Reprinted from Developmental Cell, 28, Kujawski, S., Lin, W., Kitte, F., Börmel, M., Fuchs, S., Arulmozhivarman, G., Vogt, S., Theil, D., Zhang, Y., Antos, C.L., Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins, 573-87, Copyright (2014) with permission from Elsevier. Full text @ Dev. Cell