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Fig. 6 Expression of dner partially overlaps with that of deltaA and can be inhibited by Notch activation. (A) Double in situ hybridization showing that the expression of dner (purple, black arrowheads) and deltaA (red, white arrowhead) partially overlap (arrows). (B) Expression of dner was downregulated by Notch intracellular domain (Nicd). (C) Overexpression of neurogenin1 did not lead to significant alteration in dner expression. (D) These results in B and C were confirmed by qPCR analysis. NN, p<0.01; NNN, p<0.001.
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Reprinted from Developmental Biology, 375(1), Hsieh, F.Y., Ma, T.L., Shih, H.Y., Lin, S.J., Huang, C.W., Wang, H.Y., and Cheng, Y.C., Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish, 1-12, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.