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Reprinted from Developmental Biology, 352(2), Iwafuchi-Doi, M., Yoshida, Y., Onichtchouk, D., Leichsenring, M., Driever, W., Takemoto, T., Uchikawa, M., Kamachi, Y., and Kondoh, H., The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates, 354-366, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.