ZFIN Image: Chablais et al., 2011, Fig. s4

Image

Figure Caption

Fig. s4

Sham surgery triggers a cell-cycle entry of the cardiomyocytes in the vicinity the epicardium. (A-B) The nuclei of cardiomyocytes express DsRed2-Nuc protein under the control of cmlc-2 promoter. Tropomyosin (blue) labels the myocardium, MCM5 (green) is expressed in the mitotic cells, DAPI marks all the nuclei. Proliferating cardiomyocytes are identified by the co-expression of DsRed2-Nuc and MCM5 (circles). (A′ and B′) Higher magnifications of framed area shown in left panels. (A-A′) Uninjured animals display a very few proliferating cardiomyocytes in the ventricle. (B-B′) The ventricle of animals at 4 days sham-operation contains an enhanced number of DsRed2-Nuc/MCM5-positive nuclei at the myocardial periphery, underneath the epicardium. Bars in (A-A′) represent 300 μm.

Acknowledgments

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