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Fig. 6 Excessive tbx5 positive anterior-lateral plate mesoderm formed in cdx-deficient embryos requires additional inhibition of the retinoic acid pathway in order to adopt cardiac fate and form nkx2.5 expressing cardiac cells. Shown are wildtype, cdx4-/- and cdx1/4 deficient embryos analyzed at 15-somite stage after treatment with the retinoic acid inhibitors DEAB, Ro-41-5253, or DMSO (vehicle) as a control. cdx-dose-dependent effects are observed with both inhibitors.
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Reprinted from Developmental Biology, 354(1), Lengerke, C., Wingert, R., Beeretz, M., Grauer, M., Schmidt, A.G., Konantz, M., Daley, G.Q., and Davidson, A.J., Interactions between Cdx genes and retinoic acid modulate early cardiogenesis, 134-142, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.