ZFIN ID: ZDB-GENE-980526-321
Gene Name: NK2 homeobox 5
Gene Symbol: nkx2.5
Sequence Ontology ID : SO:0000704

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Previous Names: nk2.5, nkx2-5, sb:eu581, tinman homeobox homolog, zgc:111912

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have DNA-binding activity transcription factor activity and sequence-specific DNA binding activity; involved in several processes, including animal organ development, chordate embryonic  ...
GENE EXPRESSION
All Expression Data: 209 figures from 147 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2004 [MGC:111912]
  6 figures (12 images) from Thisse et al., 2005 [eu581]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
vu179 Point Mutation Unknown Premature Stop ENU
Targeting reagents:
PHENOTYPE
Data: 32 figures from 10 publications
Observed in:
DISEASE ASSOCIATED WITH nkx2.5 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
atrial heart septal defect 7 Atrial septal defect 7, with or without AV conduction defects 108900
congenital nongoitrous hypothyroidism 5 Hypothyroidism, congenital nongoitrous, 5 225250
double outlet right ventricle Conotruncal heart malformations, variable 217095
hypoplastic left heart syndrome Hypoplastic left heart syndrome 2 614435
tetralogy of Fallot Tetralogy of Fallot 187500
ventricular septal defect Ventricular septal defect 3 614432
DISEASE ASSOCIATED WITH nkx2.5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process artery development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • InterPro:IPR033629 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nkx2.5-201 (1) 1657
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nkx2.5
    MARKER RELATIONSHIPS
    nkx2.5Contained in: [BAC] CH73-269A20 (1) (order this)
    nkx2.5Encodes: [EST] eu581 (1)
    [cDNA] MGC:111912 (1) (order this), MGC:191511 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131421 (1) 1658bp
    Genomic GenBank:CU019640 (1) 45505bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8RJR5 (1) 314aa
    Sequence Clusters UniGene:271 (1)
    Sequence Information (all 23)
    OTHER nkx2.5 GENE PAGES
  • Alliance (1)
  • Gene:30696 (1)
  • VEGA:OTTDARG00000027961 (1)
  • ORTHOLOGY for nkx2.5 (Chr: 14)
    CITATIONS (285)