ZFIN ID: ZDB-GENE-980526-321
Gene Name: NK2 homeobox 5
Gene Symbol: nkx2.5    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: nk2.5, nkx2-5, sb:eu581, tinman homeobox homolog, zgc:111912

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; embryonic viscerocranium morphogenesis; and regulation of cardiac chamber formation. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; digestive system; margin; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5).
Genome Resources: Alliance (1),  Gene:30696 (1),  Ensembl(GRCz11):ENSDARG00000018004 (1)
GENE EXPRESSION
All Expression Data: 217 figures from 154 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2004 [MGC:111912]
  6 figures (12 images) from Thisse et al., 2005 [eu581]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
vu179 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nkx2.5 N/A 3
MO2-nkx2.5 N/A 5
MO3-nkx2.5 N/A 5
DISEASE ASSOCIATED WITH nkx2.5 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial heart septal defect 7 Alliance Atrial septal defect 7, with or without AV conduction defects 108900
congenital nongoitrous hypothyroidism 5 Alliance Hypothyroidism, congenital nongoitrous, 5 225250
double outlet right ventricle Alliance Conotruncal heart malformations, variable 217095
hypoplastic left heart syndrome Alliance Hypoplastic left heart syndrome 2 614435
tetralogy of Fallot Alliance Tetralogy of Fallot 187500
ventricular septal defect Alliance Ventricular septal defect 3 614432
DISEASE ASSOCIATED WITH nkx2.5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process artery development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nkx2.5-201 (1)    Ensembl 1657
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab2-nkx2.5 polyclonal IgG Rabbit IHC Thermo Fisher Scientific (Lab Vision)
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nkx2.5
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hsp70l:nkx2.5-EGFP) hsp70l EGFPnkx2.5 Danio rerio 1 7
Tg(nkx2.5:EGFP) nkx2.5 EGFP Danio rerio 1 7
Tg(nkx2.5:fgf8a-GFP) nkx2.5 fgf8aGFP Danio rerio 1 3
Tg(nkx2.5:GAL4-VP16,myl7:EGFP) myl7nkx2.5 EGFPGAL4VP16 Danio rerio 1 3
Tg(nkx2.5:LIFEACT-GFP) nkx2.5 GFPLIFEACT Danio rerio 1 1
Tg(nkx2.5:tbx1,cryaa:Cerulean) cryaankx2.5 Ceruleantbx1 Danio rerio 1 3
Tg(nkx2.5:wnt11,myl7:EGFP) myl7nkx2.5 EGFPwnt11 Danio rerio 1 3
TgBAC(-36nkx2.5:ZsYellow) nkx2.5 ZsYellow Danio rerio 1 27
TgBAC(nkx2.5:ERT2-Cre-ERT2) nkx2.5 CreERT2 Danio rerio 1 4
TgBAC(nkx2.5:GAL4FF) nkx2.5 GAL4FF Danio rerio 1 1
TgBAC(nkx2.5:Kaede) nkx2.5 Kaede Danio rerio 1 11
MARKER RELATIONSHIPS
nkx2.5 Contained in: [BAC] CH73-269A20 (1)
nkx2.5 Encodes: [EST] eu581 (1)
[cDNA] MGC:111912 (1), MGC:191511 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131421 (1) 1658 nt
Genomic GenBank:CU019640 (1) 45505 nt
Select Tool
Polypeptide UniProtKB:A0A2R8RJR5 (1) 314 aa
Sequence Information (all 22)
ORTHOLOGY for nkx2.5 ( Chr: 14 )
CITATIONS (311)