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Fig. 6 Embryos raised at permissive temperature to dct+ stage, when shifted show no melanized cells. A) Wild-type embryo showing dct expression in retinal pigment epithelium (RPE) and neural crest melanoblasts, B) wild-type embryos 20 h after upshift (stage equivalent to 45 h at standard temperature) showing differentiated melanocytes, C) mitfafh53 embryo showing dct expression at time of temperature upshift, and D) mitfafh53 embryos 20 h after upshift do not display any melanized cells save for RPE. In A and C, embryos were treated with 0.2 mM PTU to suppress melanin synthesis.
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Reprinted from Developmental Biology, 350(2), Johnson, S.L., Nguyen, A.N., and Lister, J.A., mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell, 405-413, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.