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Fig. 1 Figure 1. Expression of apoE during pectoral fin morphogenesis. A-D: ApoE transcripts are detected starting at the onset of pectoral fin bud outgrowth and become restricted to the apical margin of the bud. Lateral view of A: 31-hr; B: 35-hr ; C: 3-day ; D: 7-day, 3 mm, zebrafish embryos and larva, anterior to the left. The red arrow in A indicates the pectoral fin bud emerging from the yolk sac. Note that apoE is strongly expressed in the yolk sac throughout development. E: pectoral fin of a 50-day, 10.3 mm, embryo. During larval stage, apoE is expressed in the epidermis of the distal part of the fin (black arrow), along the anterior margin of the fin (red arrow), and in the inter-ray tissues (white arrow). F: pectoral fin of adult fish, 32 mm. ApoE is still expressed in the pattern as during larval stage, albeit at a much lower level. y, yolk sac. Scale bar = 100 m.