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Fig. 11 Knockdown of hnf-6 perturbs pancreatic ductular development but spares acinar and endocrine cells. (A and B) Confocal projections through the pancreas of 2 dpf WT (A) and hnf-6 morphant (B) embryos processed for insulin (red) and glucagon (green). Endocrine pancreas development is normal in both embryos. (C and D) Confocal projections through the pancreas of 5 dpf WT (A) and hnf-6 morphant (B) larvae processed for insulin (red) and carboxypeptidase-A (green) IHC. A normal distribution of both markers is seen in each larva.
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Reprinted from Developmental Biology, 274(2), Matthews, R.P., Lorent, K., Russo, P., and Pack, M., The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary development, 245-259, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.