ZFIN Image: Nica et al., 2006, Fig. 5

Image

Figure Caption

Fig. 5 eya1 is required in adenohypophyseal cells. All panels show heads of chimeric zebrafish embryos at 32 hpf, with pomc transcripts in blue and transplanted wild-type cells in brown. (A, C, E) Ventral view, anterior to the top; (B, D, F) lateral view, anterior to the left. Inset in panel F shows magnified view of pituitary. Arrowheads in panels B, D, F point to pomc-positive cells in arcuate nucleus (ventral diencephalon) (Herzog et al., 2003), arrows in panels E, F to pomc-positive cells in adenohypophysis. Note that many, but not all of the transplanted wild-type cells in the adenohypophysis of the eya1 mutant in panels E, F display pomc expression. pomc-negative wild-type cells most likely represent other cell types (lactotropes, somatotropes, thyrotropes, and/or gonadotropes). Scale bars are 50 μm.

Acknowledgments

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Reprinted from Developmental Biology, 292(1), Nica, G., Herzog, W., Sonntag, C., Nowak, M., Schwarz, H., Zapata, A.G., Hammerschmidt, M., Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis, 189-204, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.