ZFIN Gene: etv5b

ZFIN ID: ZDB-GENE-991228-4

ZFIN ID: ZDB-GENE-991228-4

Gene Name:

ETS variant transcription factor 5b

Gene Symbol:

etv5b Nomenclature History

Previous Names:

cb805 (1), erm1 (1), erm, wu:fe05h04, wu:fj66a04

Gene Type:

protein_coding_gene

Location:

Chr: 6 Mapping Details/Browsers

Description:

Exhibits sequence-specific DNA binding activity. Involved in several processes, including limb morphogenesis; nervous system development; and pronephros development. Predicted to localize to nucleus. Is expressed in several structures, including brain; eye; mesoderm; neural plate; and pharyngeal arch. Orthologous to human ETV5 (ETS variant transcription factor 5).

Genome Resources:

Alliance (1), Gene:30452 (1), Ensembl(GRCz11):ENSDARG00000044511 (1)

GENE EXPRESSION
All Expression Data:	80 figures from 60 publications
Directly Submitted Expression Data:	6 figures (34 images) from Thisse et al., 2001 [cb805]
Wild-type Stages, Structures:	Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
	blastoderm brain caudal tuberculum ceratobranchial bone ceratohyal cartilage cerebellar crest corpus cerebelli diencephalon ectoderm epiphysis eye forebrain ventral region forebrain forebrain neural keel forerunner cell group gut hindbrain anterior region hindbrain hindbrain neural keel hindbrain neural plate hindbrain neural rod hypothalamus immature eye mesoderm midbrain hindbrain boundary midbrain hindbrain boundary neural keel midbrain hindbrain boundary neural plate neural plate neural tube optic stalk optic tectum otic placode otic vesicle anterior crista otic vesicle palatoquadrate arch paraxial mesoderm pectoral fin pectoral fin bud mesenchyme pectoral fin bud pectoral fin field pectoral fin musculature pharyngeal arch 1 cranial neural crest pharyngeal arch 2 cranial neural crest pharyngeal arch 2 skeleton pharyngeal arch 3 cranial neural crest pharyngeal arch 3 skeleton pharyngeal arch 3-7 pharyngeal arch 3-7 skeleton pharyngeal arch 4 cranial neural crest pharyngeal pouch pineal complex anterior region posterior lateral plate mesoderm posterior recess anatomical region presumptive rhombomere 4 retina retinal ganglion cell layer rhombomere segmental plate somite spinal cord tail bud tegmentum telencephalon torus longitudinalis unspecified ventral hyoid arch ventricular zone whole organism anterior region whole organism posterior region whole organism yolk syncytial layer
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la029178Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa30870	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40656	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-etv5b	N/A	3
MO2-etv5b	N/A	3
MO3-etv5a,etv5b	N/A	1
MO3-etv5b	N/A	2
MO4-etv5a,etv5b	N/A	1

PHENOTYPE

Data:	3 figures from 2 publications
Observed in:	hypothalamus mitotic S phase hypothalamus motor neuron axon serotonin secreting cell

DISEASE ASSOCIATED WITH etv5b HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH etv5b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	limb morphogenesis (more)
Cellular Component	nucleus (more)
Molecular Function	sequence-specific DNA binding (more)

GO Terms (all 13)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	etv5b-201 (1)	2837	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM etv5b

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(-5etv5b:GAL4-VP16)	etv5b	GAL4, VP16	Danio rerio	1	5

MARKER RELATIONSHIPS

etv5b Contained in:	[BAC] DKEY-29F19 (1) (order this), DKEYP-78G2 (1)
etv5b Encodes:	[EST] cb805 (1) (order this), fe05h04, fj66a04 [cDNA] MGC:73250 (1), MGC:173964 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131205 (1)	2779 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX323042 (1)	206473 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:A0A2R8QC01 (1)	526 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 36)

ORTHOLOGY for etv5b ( Chr: 6 )

CITATIONS (128)

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